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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.1
- 수록면
- 300 - 307 (8page)
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Background The antiviral agent favipiravir is an RNA-dependent RNA polymerase (RdRp) inhibitor. Materials and Methods We examined patients with a clinical, laboratory, and radiological diagnosis of severe coronavirus disease 2019 (COVID-19) pneumonia. We investigated the effect of administering enteral favipiravir at a 2 × 1,600 mg loading dose and 2 × 600 mg maintenance dose for 5 days in addition to the standard COVID-19 treatment. Results In total, 180 patients, who were hospitalized at the Istanbul Tuzla State Hospital and received favipiravir treatment between March 20, 2020 and May 30, 2020, were examined. Of these, 47 patients died. Thirty-three of the patients who died were aged over 65 years (70%), indicating that fatality was higher in elderly patients. Most of those who died had at least one comorbidity. Of the 101 patients who initiated favipiravir within ≤3 days of hospitalization, 17 died (17%). Of the 79 patients who initiated favipiravir after >3 days of hospitalization, 30 died (38%) (P = 0.002). Conclusion We found that initiation of favipiravir within the first 72 h after the onset of disease symptoms reduced fatality in patients with COVID-19.
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참고문헌 (27)
참고문헌 신청
Sallenave JM / 2020 / Innate immune signaling and proteolytic pathways in the resolution or exacerbation of SARS-CoV-2 in Covid-19: key therapeutic Targets? / Front Immunol 11:1229
Helmy YA / 2020 / The COVID-19 pandemic: a comprehensive review of taxonomy, genetics, epidemiology, diagnosis, treatment, and control / J Clin Med 9:1225
Han W / 2020 / The course of clinical diagnosis and treatment of a case infected with coronavirus disease 2019 / J Med Virol 2:61~63
Furuta Y / 2017 / Favipiravir (T-705), a broad spectrum inhibitor of viral RNA polymerase / Proc Jpn Acad Ser B Phys Biol Sci 93:449~463
Joshi S / 2021 / Role of favipiravir in the treatment of COVID-19 / Int J Infect Dis 102:501~508
Helmy YA / 2020 / The COVID-19 pandemic: a comprehensive review of taxonomy, genetics, epidemiology, diagnosis, treatment, and control / J Clin Med 9:1225
Han W / 2020 / The course of clinical diagnosis and treatment of a case infected with coronavirus disease 2019 / J Med Virol 2:61~63
Furuta Y / 2017 / Favipiravir (T-705), a broad spectrum inhibitor of viral RNA polymerase / Proc Jpn Acad Ser B Phys Biol Sci 93:449~463
Joshi S / 2021 / Role of favipiravir in the treatment of COVID-19 / Int J Infect Dis 102:501~508
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