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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 339 - 345 (7page)
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초록· 키워드
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Background: Intermittent dosing regimens for oral risedronate (once-monthly and once-weekly) were developed for patient convenience. While several studies have reported the anti-fracture efficacy of weekly dosing, few have assessed monthly dosing. The lower efficacy of monthly dosing has been previously suggested. The aim of this study was to compare the anti-fracture efficacy of monthly and weekly dosing. Methods: We obtained information from the Korea National Health Insurance Service database from 2012 to 2017 of Korean women of ≥50 years of age who used weekly or monthly risedronate. We compared the time of occurrence of the first osteoporotic fracture after the first prescription of risedronate. Using a Cox proportional model, we assessed incidence rate ratios (IRRs) with 95% confidence intervals (CIs) for fractures at any site, and the hip, vertebral, and non-vertebral sites between both regimens. Propensity score weighting was used to balance the treatment groups. Results: The study populations were distributed according to dosing frequency (monthly, 27,329; weekly, 47,652). There was no significant difference in the incidence rate of new fractures in any site (IRR, 1.008; 95% CI, 0.963? 1.055; P=0.737), hip (IRR, 0.999; 95% CI, 0.769?1.298; P=0.996), vertebral (IRR, 0.962; 95% CI, 0.890?1.040; P=0.330), or non-vertebral (1.022; 95% CI, 0.968?1.078; P=0.439) sites between monthly and weekly risedronate. Conclusion: The anti-fracture efficacy at any site and the examined individual sites was similar for the monthly and weekly risedronate regimens. Large-scale randomized controlled trials are required for confirmation.
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등록된 정보가 없습니다.
참고문헌 (30)
참고문헌 신청
하용찬 / 2016 / 한국 골다공증의 역학 / 대한의사협회지 59(11):836~841
박은정 / 2014 / Prevalence of Osteoporosis in the Korean Population Based on Korea National Health and Nutrition Examination Survey (KNHANES), 2008--2011 / Yonsei Medical Journal 55(4):1049~1057
하용찬 / 2015 / Trend in Hip Fracture Incidence and Mortality in Korea: A Prospective Cohort Study from 2002 to 2011 / Journal of Korean Medical Science 30(4):483~488
Bliuc D / 2009 / Mortality risk associated with low-trauma osteoporotic fracture and subsequent fracture in men and women / JAMA 301:513~521
Ha YC / 2017 / Economic burden of osteoporosis in South Korea : claim data of the National Health Insurance Service from 2008 to 2011 / Calcif Tissue Int 101:623~630
박은정 / 2014 / Prevalence of Osteoporosis in the Korean Population Based on Korea National Health and Nutrition Examination Survey (KNHANES), 2008--2011 / Yonsei Medical Journal 55(4):1049~1057
하용찬 / 2015 / Trend in Hip Fracture Incidence and Mortality in Korea: A Prospective Cohort Study from 2002 to 2011 / Journal of Korean Medical Science 30(4):483~488
Bliuc D / 2009 / Mortality risk associated with low-trauma osteoporotic fracture and subsequent fracture in men and women / JAMA 301:513~521
Ha YC / 2017 / Economic burden of osteoporosis in South Korea : claim data of the National Health Insurance Service from 2008 to 2011 / Calcif Tissue Int 101:623~630
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