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논문 기본 정보

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학술저널
저자정보
Feng Jun (Department of Critical Care Medicine Tongji Hospital Tongji Medical College Huazhong University of) Fang Bangjiang (Department of Emergency Medicine LongHua Hospital Shanghai University of Traditional Chinese Medici) Zhou Daixing (Department of Critical Care Medicine Tongji Hospital Tongji Medical College Huazhong University of) Wang Junshuai (Department of Critical Care Medicine Tongji Hospital Tongji Medical College Huazhong University of) Zou Dengxiu (Department of Critical Care Medicine Tongji Hospital Tongji Medical College Huazhong University of) Yu Gang (Department of Critical Care Medicine Tongji Hospital Tongji Medical College Huazhong University of) Fen Yikuan (Department of Critical Care Medicine Tongji Hospital Tongji Medical College Huazhong University of) Peng Dan (Department of Critical Care Medicine Tongji Hospital Tongji Medical College Huazhong University of) Hu Jifa (Office of Academic Research Tongji Hospital Tongji Medical College Huazhong University of Science a) Zhan Daqian (Department of Critical Care Medicine Tongji Hospital Tongji Medical College Huazhong University of)
저널정보
한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제31권 제3호
발행연도
2021.1
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380 - 386 (7page)

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The coronavirus disease 2019 (COVID-19) pandemic has become a public health emergency of global concern. In China, traditional Chinese medicine has been widely administered to COVID-19 patients without sufficient evidence. To evaluate the efficacy of Shenhuang Granule (SHG) for treating critically ill patients with COVID-19, we included in this study 118 patients who were admitted to the ICU of Tongji Hospital between January 28, 2020 and March 28, 2020. Among these patients, 33 (27.9%) received standard care plus SHG (treatment group) and 85 (72.1%) received standard care alone (control group). Enrolled patients had a median (IQR) age of 68 (57-75) years, and most (79 [67.1%]) were men. At end point of this study, 83 (70.3%) had died in ICU, 29 (24.5%) had been discharged from ICU, and 6 patients (5.2%) were still in ICU. Compared with control group, mortality was significantly lower in treatment group (45.4% vs. 80%, p < .001). Patients in treatment group were less likely to develop acute respiratory distress syndrome (ARDS) (12 [36.3%] vs. 54 [63.5%], p = 0.012) and cardiac injury (5 [15.1%] vs. 32 [37.6%], p = 0.026), and less likely to receive mechanical ventilation (22 [66.7%] vs. 72 [84.7%], p = 0.028) than those in control group. The median time from ICU admission to discharge was shorter in treatment group (32 [20?73] days vs. 76 [63?79] days, p = 0.0074). These findings suggest that SHG treatment as a complementary therapy might be effective for critically ill adults with COVID-19 and warrant further clinical trials.
#Coronavirus disease 2019 #traditional Ch Received: September 16 #2020 inese medicine #Shenhuang Granule #inflammation

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참고문헌 (33)

참고문헌 신청
Helmy YA / 2020 / The COVID-19 pandemic : a comprehensive review of taxonomy, genetics, epidemiology, diagnosis, treatment, and control / J. Clin. Med 9:1225 google schola Weiss P / 2020 / Clinical course and mortality risk of severe COVID-19 / Lancet 395:1014~1015 google schola Wu C / 2020 / Risk factors associated with acute respiratory distress syndrome and death in patients with coronavirus disease 2019 pneumonia in Wuhan, China / JAMA Intern. Med 180:934~943 google schola Onder G / 2020 / Case-fatality rate and characteristics of patients dying in relation to COVID-19 in Italy / JAMA 323:1775~1776 google schola Poston JT / 2020 / Management of critically ill adults with COVID-19 / JAMA 323:1839~1841 google schola

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