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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제30권 제9호
- 발행연도
- 2020.1
- 수록면
- 1,379 - 1,386 (8page)
이용수
초록· 키워드
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Acne is a chronic skin disease that typically occurs in the teens and twenties, and its symptoms vary according to age, sex, diet, and lifestyle. The condition is characterized by hyperproliferation of keratinocytes in the epidermis, sebum overproduction, excessive growth of Propionibacterium acnes, and P. acnes-induced skin inflammation. Interleukin (IL)-1α and IL-6 are predominant in the inflammatory lesions of acne vulgaris. These cytokines induce an inflammatory reaction in the skin in the presence of pathogens or stresses. Moreover, IL-1α accelerates the production of keratin 16, which is typically expressed in wounded or aberrant skin, leading to abnormalities in architecture and hyperkeratinization. Orobol (3’,4’,5,7-tetrahydroxyisoflavone) is a metabolite of genistein that inhibited the P. acnes-induced increases in IL-6 and IL-1α levels in human keratinocytes (HaCaTs) more effectively compared with salicylic acid. In addition, orobol decreased the IL-1α and IL-6 mRNA levels and inhibited the phosphorylation of inhibitor of kappa-B kinase, nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha, and mitogen-activated protein kinase induced by P. acnes. Finally, the expression of Ki67 was decreased by orobol. Thus, orobol ameliorated the inflammation and hyperkeratinization induced by heat-killed P. acnes and thus has potential for use in functional foods and cosmetics.
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등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Cong TX / 2019 / From pathogenesis of acne vulgaris to anti-acne agents / Arch. Dermatol. Res 311:337~349
Samuels DV / 2020 / Acne vulgaris and risk of depression and anxiety : a meta-analytic review / J. Am. Acad. Dermatol 83:532~541
Kassir M / 2020 / Selective RAR agonists for acne vulgaris : a narrative review / J. Cosmet. Dermatol 19:1278~1283
Marron SE / 2019 / Quality-of-life research in acne vulgaris : current status and future directions / Am. J. Clin. Dermatol 20:527~538
Valente Duarte / 2014 / Novel pharmacological approaches for the treatment of acne vulgaris / Expert. Opin. Investig. Drugs 23:1389~1410
Samuels DV / 2020 / Acne vulgaris and risk of depression and anxiety : a meta-analytic review / J. Am. Acad. Dermatol 83:532~541
Kassir M / 2020 / Selective RAR agonists for acne vulgaris : a narrative review / J. Cosmet. Dermatol 19:1278~1283
Marron SE / 2019 / Quality-of-life research in acne vulgaris : current status and future directions / Am. J. Clin. Dermatol 20:527~538
Valente Duarte / 2014 / Novel pharmacological approaches for the treatment of acne vulgaris / Expert. Opin. Investig. Drugs 23:1389~1410
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