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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.1
- 수록면
- 214 - 222 (9page)
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Phosphatidylserine (PS), a negatively charged phospholipid exclusively located in the inner leaflet of the plasma membrane, is involved in various cellular processes such as blood coagulation, myoblast fusion, mammalian fertilization, and clearance of apoptotic cells. Proteins that specifically interact with PS must be identified to comprehensively understand the cellular processes involving PS. However, only a limited number of proteins are known to associate with PS. To identify PS-associating proteins, we performed a pulldown assay using streptavidin-coated magnetic beads on which biotin-linked PS was immobilized. Using this approach, we identified Hsd17b4, a peroxisomal protein, as a PS-associating protein. Hsd17b4 strongly associated with PS, but not with phosphatidylcholine or sphingomyelin, and the Scp-2-like domain of Hsd17b4 was responsible for this association. The association was disrupted by PS in liposomes, but not by free PS or the components of PS. In addition, translocation of PS to the outer leaflet of the plasma membrane enriched Hsd17b4 in peroxisomes. Collectively, this study suggests an unexpected role of PS as a regulator of the subcellular localization of Hsd17b4.
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참고문헌 (39)
참고문헌 신청
Boada-Romero, E. / 2020 / The clearance of dead cells by efferocytosis / Nat. Rev. Mol. Cell Biol. 21:398~414
Choi, Y. / 2006 / Chemical genetic identification of the IGF-linked pathway that is mediated by STAT6 and MFP2 / Chem. Biol 13:241~249
Clark, M. R / 2011 / Flippin' lipids / Nat. Immunol 12:373~375
Elliott, J. I. / 2005 / Membrane phosphatidylserine distribution as a non-apoptotic signalling mechanism in lymphocytes / Nat. Cell Biol 7:808~816
Fadok, V. A. / 1992 / Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages / J. Immunol 148:2207~2216
Choi, Y. / 2006 / Chemical genetic identification of the IGF-linked pathway that is mediated by STAT6 and MFP2 / Chem. Biol 13:241~249
Clark, M. R / 2011 / Flippin' lipids / Nat. Immunol 12:373~375
Elliott, J. I. / 2005 / Membrane phosphatidylserine distribution as a non-apoptotic signalling mechanism in lymphocytes / Nat. Cell Biol 7:808~816
Fadok, V. A. / 1992 / Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages / J. Immunol 148:2207~2216
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