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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 605 - 610 (6page)
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초록· 키워드
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Skeletal myogenesis is a complex process that is finely regulated by myogenic transcription factors. Recent studies have shown that saturated fatty acids (SFA) can suppress the activation of myogenic transcription factors and impair the myogenic differentiation of progenitor cells. Despite the increasing evidence of the roles of miRNAs in myogenesis, the targets and myogenic regulatory mechanisms of miRNAs are largely unknown, particularly when myogenesis is dysregulated by SFA deposition. This study examined the implications of SFA-induced miR-183-5p on the myogenic differentiation in C2C12 myoblasts. Long-chain SFA palmitic acid (PA) drastically reduced myogenic transcription factors, such as myoblast determination protein (MyoD), myogenin (MyoG), and myocyte enhancer factor 2C (MEF2C), and inhibited FHL1 expression and myogenic differentiation of C2C12 myoblasts, accompanied by the induction of miR-183-5p. The knockdown of FHL1 by siRNA inhibited myogenic differentiation of myoblasts. Interestingly, miR-183-5p inversely regulated the expression of FHL1, a crucial regulator of skeletal myogenesis, by targeting the 3'UTR of FHL1 mRNA. Furthermore, the transfection of miR-183-5p mimic suppressed the expression of MyoD, MyoG, MEF2C, and MyHC, and impaired the differentiation and myotube formation of myoblasts. Overall, this study highlights the role of miR-183-5p in myogenic differentiation through FHL1 repression and suggests a novel miRNA-mediated mechanism for myogenesis in a background of obesity.
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참고문헌 (32)
참고문헌 신청
Chal J / 2017 / Making muscle : skeletal myogenesis in vivo and in vitro / Development 144:2104~2122
Asfour HA / 2018 / Myogenic regulatory factors : The orchestrators of myogenesis after 30 years of discovery / Exp Biol Med (Maywood) 243:118~128
Benarroch L / 2019 / The 2020 version of the gene table of neuromuscular disorders(nuclear genome) / Neuromuscul Disord 29:980~1018
Akhmedov D / 2013 / The effects of obesity on skeletal muscle regeneration / Front Physiol 4:371
Chang YC / 2018 / Resveratrol protects muscle cells against palmitate-induced cellular senescence and insulin resistance through ameliorating autophagic flux / J Food Drug Anal 26:1066~1074
Asfour HA / 2018 / Myogenic regulatory factors : The orchestrators of myogenesis after 30 years of discovery / Exp Biol Med (Maywood) 243:118~128
Benarroch L / 2019 / The 2020 version of the gene table of neuromuscular disorders(nuclear genome) / Neuromuscul Disord 29:980~1018
Akhmedov D / 2013 / The effects of obesity on skeletal muscle regeneration / Front Physiol 4:371
Chang YC / 2018 / Resveratrol protects muscle cells against palmitate-induced cellular senescence and insulin resistance through ameliorating autophagic flux / J Food Drug Anal 26:1066~1074
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