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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 349 - 356 (8page)
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초록· 키워드
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Mass spectrometry (MS) is an ideal tool for analyzing multiple types of (bio)molecular information simultaneously in complex biological systems. In addition, MS provides structural information on targets, and can easily discriminate between true analytes and background. Therefore, imaging mass spectrometry (IMS) enables not only visualization of tissues to give positional information on targets but also allows for molecular analysis of targets by affording the molecular weights. Matrixassisted laser desorption/ionization-time of flight (MALDI-TOF) MS is particularly effective and is generally used for IMS. However, the requirement for an organic matrix raises several limitations that get in the way of accurate and reliable images and hampers imaging of small molecules such as drugs and their metabolites. To overcome these problems, various organic matrix-free LDI IMS systems have been developed, mostly utilizing nanostructured surfaces and inorganic nanoparticles as an alternative to the organic matrix. This minireview highlights and focuses on the progress in organic matrix-free LDI IMS and briefly discusses the use of other IMS techniques such as desorption electrospray ionization, laser ablation electrospray ionization, and secondary ion mass spectrometry.
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참고문헌 (69)
참고문헌 신청
Chughtai K / 2010 / Mass Spectrometric Imaging for Biomedical Tissue Analysis / Chem Rev 110:3237~3277
Buchberger AR / 2018 / Mass Spectrometry Imaging : A Review of Emerging Advancements and Future Insights / Anal Chem 90:240~265
Xu X / 2019 / A brief review on mass/optical spectrometry for imaging analysis of biological samples / Appl Spectrom Rev 54(1):57~85
Tanaka K / 1988 / Protein and Polymer Analyses up to m/z 100 000by Laser Ionization Time-of-flight Mass Spectrometry / Rapid Commun Mass Spectrom 2:151~156
Karas M / 1988 / Laser Desorption Ionziation of Proteins with Molecular Masses Exceeding 10, 000 Daltons / Anal Chem 60:2299~2301
Buchberger AR / 2018 / Mass Spectrometry Imaging : A Review of Emerging Advancements and Future Insights / Anal Chem 90:240~265
Xu X / 2019 / A brief review on mass/optical spectrometry for imaging analysis of biological samples / Appl Spectrom Rev 54(1):57~85
Tanaka K / 1988 / Protein and Polymer Analyses up to m/z 100 000by Laser Ionization Time-of-flight Mass Spectrometry / Rapid Commun Mass Spectrom 2:151~156
Karas M / 1988 / Laser Desorption Ionziation of Proteins with Molecular Masses Exceeding 10, 000 Daltons / Anal Chem 60:2299~2301
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