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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Purpose: Gafchromic films for proton dosimetry are dependent on linear energy transfers (LETs), resulting in dose underestimation for high LETs. Despite efforts to resolve this problem for singleenergy beams, there remains a need to do so for multi-energy beams. Here, a bimolecular reaction model was applied to correct the under-response of spread-out Bragg peaks (SOBPs). Methods: For depth-dose measurements, a Gafchromic EBT3 film was positioned in water perpendicular to the ground. The gantry was rotated at 15° to avoid disturbances in the beam path. A set of films was exposed to a uniformly scanned 112-MeV pristine proton beam with six different dose intensities, ranging from 0.373 to 4.865 Gy, at a 2-cm depth. Another set of films was irradiated with SOBPs with maximum energies of 110, 150, and 190 MeV having modulation widths of 5.39, 4.27, and 5.34 cm, respectively. The correction function was obtained using 150.8-MeV SOBP data. The LET of the SOBP was then analytically calculated. Finally, the model was validated for a uniform cubic dose distribution and compared with multilayered ionization chamber data. Results: The dose error in the plateau region was within 4% when normalized with the maximum dose. The discrepancy of the range was <1 mm for all measured energies. The highest errors occurred at 70 MeV owing to the steep gradient with the narrowest Bragg peak. Conclusions: With bimolecular model-based correction, an EBT3 film can be used to accurately verify the depth dose of scanned proton beams and could potentially be used to evaluate the depth-dose distribution for patient plans.
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참고문헌 (20)
참고문헌 신청
International Commission on Radiation Units & Measurements / 2009 / Prescribing, recording, and reporting proton-beam therapy :60~62
Schaffner B / 1999 / Dose calculation models for proton treatment planning using a dynamic beam delivery system : an attempt to include density heterogeneity effects in the analytical dose calculation / Phys Med Biol 44:27~41
Sorriaux J / 2013 / Evaluation of Gafchromic®EBT3 films characteristics in therapy photon, electron and proton beams / Phys Med 29:599~606
Reinhardt S / 2012 / Comparison of Gafchromic EBT2 and EBT3 films for clinical photon and proton beams / Med Phys 39:5257~5262
Arjomandy B / 2010 / Energy dependence and dose response of Gafchromic EBT2 film over a wide range of photon, electron, and proton beam energies / Med Phys 37:1942~1947
Schaffner B / 1999 / Dose calculation models for proton treatment planning using a dynamic beam delivery system : an attempt to include density heterogeneity effects in the analytical dose calculation / Phys Med Biol 44:27~41
Sorriaux J / 2013 / Evaluation of Gafchromic®EBT3 films characteristics in therapy photon, electron and proton beams / Phys Med 29:599~606
Reinhardt S / 2012 / Comparison of Gafchromic EBT2 and EBT3 films for clinical photon and proton beams / Med Phys 39:5257~5262
Arjomandy B / 2010 / Energy dependence and dose response of Gafchromic EBT2 film over a wide range of photon, electron, and proton beam energies / Med Phys 37:1942~1947
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