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논문 기본 정보

자료유형
학술저널
저자정보
신윤민 (대전대학교 한의과대학 분자의학실험실) 임형택 (자하연한의원) 황은영 (자하연한의원) 김가나 (자하연한의원) 이원길 (대전대학교 한의과대학 분자의학실험실) 김연경 (대전대학교 한의과대학 분자의학실험실) 장희진 (대전대학교 한의과대학 분자의학실험실) 최정준 (대전대학교 한의과대학 분자의학실험실)
저널정보
대한한방신경정신과학회 동의신경정신과학회지 동의신경정신과학회지 제32권 제1호
발행연도
2021.1
수록면
25 - 37 (13page)

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Objectives: Depression is a mood disorder showing low energy, loss of interest, anhedonia, and anxiety. It affects a patients' daily life. This disease is considered a social problem because the patient may commit suicide in extreme cases. JSB is composed of 12 Korean medicinal herbs. It has been prescribed to patients with depression. The objective of this study is to investigate anti-depressive effects of JSB on restraint stress-induced depression in a mouse model. Methods: Depression was induced by restraint stress. Mice were orally administered JSB at 10, 20, or 40 mg/kg for 14 days. Forced swimming test (FST) and open field test (OFT) were performed. Brain-derived neurotrophic factor (BDNF) mRNA level was measured by real time-PCR. Plasma levels of corticosterone and serotonin were measured by ELISA. Blood levels of AST and ALS were measured using a biochemical analyzer. Results: JSB treatment significantly reduced the immobility time in FST. BDNF mRNA level was increased by JSB treatment in the hippocampi of mice. Although the expression of TNF-α was also increased by JSB, such increase was not statistically significant. The increase of corticosterone level in plasma induced by restraint stress was significantly down-regulated by JSB. JSB reduced blood level of AST, but not ALT. Conclusions: JSB has a potential to manage depression, setting a foundation for clinical application of Korean medicine with safety.

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