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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
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- 대한소아소화기영양학회 Pediatric Gastroenterology, Hepatology & Nutrition Pediatric Gastroenterology, Hepatology & Nutrition 제24권 제1호
- 발행연도
- 2021.1
- 수록면
- 30 - 37 (8page)
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Purpose: To investigate the differences in the colon microbiota composition of Hirschsprung's disease (HSCR) patients with and without a history of postoperative Hirschsprung's associated enterocolitis (HAEC). Methods: Colon tissue microbiota was characterized by bacterial deoxyribonucleic acid (DNA) extraction and 16S rDNA sequencing for taxonomic classification and comparison. Results: The sequence diversity richness within samples was significantly higher in samples from patients with a history of postoperative HAEC. We observed an increased relative abundance of the phyla Bacteroidetes, Firmicutes and Cyanobacteria in HAEC patients and Fusobacteria, Actinobacteria and Proteobacteria in HSCR patients and, an increased relative abundance of the genera Dolosigranulum, Roseouria and Streptococcus in HAEC patients and Propionibacterium and Delftia in HSCR patients. Conclusion: Our findings provide evidence that the colon tissue microbiota composition is different in HSCR patients with and without postoperative HAEC.
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참고문헌 (17)
참고문헌 신청
Huang WK / 2018 / Prevalence, risk factors, and prognosis of postoperative complications after surgery for Hirschsprung disease / J Gastrointest Surg 22:335~343
Pini Prato A / 2011 / Hirschsprung's disease: what about mortality? / Pediatr Surg Int 27:473~478
Elhalaby EA / 1995 / Enterocolitis associated with Hirschsprung's disease : a clinical histopathological correlative study / J Pediatr Surg 30:1023~1026
Frykman PK / 2015 / Characterization of bacterial and fungal microbiome in children with Hirschsprung disease with and without a history of enterocolitis: a multicenter study / PLoS One 10:e0124172
Shen DH / 2009 / Detection of intestinal bifidobacteria and lactobacilli in patients with Hirschsprung's disease associated enterocolitis / World J Pediatr 5:201~205
Pini Prato A / 2011 / Hirschsprung's disease: what about mortality? / Pediatr Surg Int 27:473~478
Elhalaby EA / 1995 / Enterocolitis associated with Hirschsprung's disease : a clinical histopathological correlative study / J Pediatr Surg 30:1023~1026
Frykman PK / 2015 / Characterization of bacterial and fungal microbiome in children with Hirschsprung disease with and without a history of enterocolitis: a multicenter study / PLoS One 10:e0124172
Shen DH / 2009 / Detection of intestinal bifidobacteria and lactobacilli in patients with Hirschsprung's disease associated enterocolitis / World J Pediatr 5:201~205
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