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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Hyperlipidemia is an important risk factor for ischemic stroke; the Stroke Prevention by Aggressive Reduction in Cholesterol Level and Treat Stroke to Target studies have shown that statins are beneficial for patients with stroke and that a low target for low-density lipoprotein cholesterol (LDL-C) concentration may maximize this benefit. Based on these results, recent guidelines have emphasized the application of “high-intensity statins” and “low LDL-C target” strategies in patients with stroke. However, it should be kept in mind that the role of blood lipids as a risk factor and benefit of lipid-lowering therapy are different among patients with different levels of cerebral arterial diseases. Studies have suggested that hypolipidemia, but not hyperlipidemia, is a risk factor for small vessel diseases (SVDs) such as intracerebral hemorrhages, microbleeds, white matter hyperintensities, and perhaps, lacunar infarction. Although lipid-lowering agents might benefit certain patients with SVD, high-intensity statin and low LDL-C target strategies cannot be applied. In contrast, these strategies are important in patients with extracranial atherosclerosis, such as internal carotid disease, considering ample evidence of the benefits of lipid-lowering agents. Imaging studies have shown that statins stabilize vulnerable plaques in these patients. Although lipid-lowering agents are likely to benefit patients with intracranial atherosclerosis, the degree of their benefit and appropriate target LDL-C level for these patients remain unclear. More studies are needed to elucidate the appropriate lipid-modifying strategies in patients with stroke with different levels of cerebral artery disease.
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등록된 정보가 없습니다.
참고문헌 (74)
참고문헌 신청
Shahar E / 2003 / Plasma lipid profile and incident ischemic stroke : the Atherosclerosis Risk in Communities(ARIC)study / Stroke 34:623~631
Cholesterol Treatment Trialists’(CTT)Collaboration / 2010 / Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170,000 participants in 26 randomised trials / Lancet 376:1670~1681
Collins R / 2004 / Effects of cholesterol-lowering with simvastatin on stroke and other major vascular events in 20536 people with cerebrovascular disease or other high-risk conditions / Lancet 363:757~767
Amarenco P / 2006 / High-dose atorvastatin after stroke or transient ischemic attack / N Engl J Med 355:549~559
Amarenco P / 2007 / Effects of intense low-density lipoprotein cholesterol reduction in patients with stroke or transient ischemic attack : the Stroke Prevention by Aggressive Reduction in Cholesterol Levels(SPARCL)trial / Stroke 38:3198~3204
Cholesterol Treatment Trialists’(CTT)Collaboration / 2010 / Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170,000 participants in 26 randomised trials / Lancet 376:1670~1681
Collins R / 2004 / Effects of cholesterol-lowering with simvastatin on stroke and other major vascular events in 20536 people with cerebrovascular disease or other high-risk conditions / Lancet 363:757~767
Amarenco P / 2006 / High-dose atorvastatin after stroke or transient ischemic attack / N Engl J Med 355:549~559
Amarenco P / 2007 / Effects of intense low-density lipoprotein cholesterol reduction in patients with stroke or transient ischemic attack : the Stroke Prevention by Aggressive Reduction in Cholesterol Levels(SPARCL)trial / Stroke 38:3198~3204
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