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논문 기본 정보

자료유형
학술저널
저자정보
Mi-Yeon Eun (Department of Neurology Kyungpook National University Chilgok HospitalDaegu Korea) Jae-Young Kim (Department of NeurologySamsung Medical CenterSeoulKorea) Yang-Ha Hwang (Department of Neurology Kyungpook National University Hospital Daegu Korea) Man-Seok Park (Department of Neurology Chonnam National University Hospital GwangjuKorea) Joon-Tae Kim (Department of Neurology Chonnam National University Hospital Gwangju Korea) Kang-Ho Choi (Department of Neurology Chonnam National University Hospital Gwangju Korea) Jin-Man Jung (Department of Neurology Korea University Ansan Hospital Ansan Korea) Sungwook Yu (Department of Neurology Korea University Anam Hospital Seoul Korea) Chi Kyung Kim (Department of Neurology Korea University Guro HospitalSeoul Korea) Kyungmi Oh (Department of Neurology Korea University Guro HospitalSeoul Korea) Tae-Jin Song (Department of Neurology Ewha Womans University Seoul Hospital Seoul Korea) Yong-Jae Kim (Department of Neurology Eunpyeong St. Mary’s Hospital Seoul Korea) Bum Joon Kim (Department of Neurology Asan Medical Center University of Ulsan College of Medicine Seoul Korea) Sung Hyuk Heo (Department of Neurology Kyung Hee University Hospital Seoul Korea) Kwang-Yeol Park (Department of Neurology Chung-Ang University Hospital Seoul Korea) Jeong-Min Kim (Department of Neurology Chung-Ang University Hospital Seoul Korea) Jong-Ho Park (Department of Neurology Myongji Hospital Hanyang University College of Medicine Goyang Korea) Jay Chol Choi (Department of Neurology Jeju National University Hospital Jeju Korea) Jong-Won Chung (Department of Neurology Samsung Medical Center Seoul Korea) Oh Young Bang (Department of Neurology Samsung Medical Center Seoul Korea) Gyeong-Moon Kim (Department of Neurology Samsung Medical Center Seoul Korea) Woo-Keun Seo (Department of Neurology Samsung Medical Center Seoul Korea)
저널정보
대한뇌졸중학회 대한뇌졸중학회지 대한뇌졸중학회지 제23권 제1호
발행연도
2021.1
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113 - 123 (11page)

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Background and Purpose: To evaluate the outcome events and bleeding complications of the European Society of Cardiology (ESC) guideline-matched oral anticoagulant therapy for patients with acute ischemic stroke and atrial fibrillation (AF). Methods: Patients with acute ischemic stroke and AF from a nationwide multicenter registry(Korean ATrial fibrillaTion EvaluatioN regisTry in Ischemic strOke patieNts [K-ATTENTION]) between January 2013 and December 2015 were included in the study. Patients were divided into the ESC guideline- matched and the non-matched groups. The primary outcome was recurrence of any stroke during the 90-day follow-up period. Secondary outcomes were major adverse cerebrovascular and cardiovascular events, ischemic stroke, intracranial hemorrhage, acute coronary syndrome, allcause mortality, and major hemorrhage. Propensity score matching and logistic regression analyses were performed to assess the effect of the treatments administered. Results: Among 2,321 eligible patients, 1,126 patients were 1:1 matched to the ESC guidelinematched and the non-matched groups. As compared with the non-matched group, the ESC guideline- matched group had a lower risk of any recurrent stroke (1.4% vs. 3.4%; odds ratio[OR], 0.41; 95% confidence interval [CI], 0.18 to 0.95). The risk of recurrent ischemic stroke was lower in the ESC guideline-matched group than in the non-matched group (0.9% vs. 2.7%; OR, 0.32; 95% CI, 0.11 to 0.88). There was no significant difference in the other secondary outcomes between the two groups. Conclusions: ESC guideline-matched oral anticoagulant therapy was associated with reduced risks of any stroke and ischemic stroke as compared with the non-matched therapy.
#Stroke #Atrial fibrillation #Guideline #Anticoagulants #Outcome

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참고문헌 (25)

참고문헌 신청
Hart RG / 2007 / Meta-analysis : antithrombotic therapy to prevent stroke in patients who have nonvalvular atrial fibrillation / Ann Intern Med 146:857~867 google schola Saxena R / 2004 / Anticoagulants versus antiplatelet therapy for preventing stroke in patients with nonrheumatic atrial fibrillation and a history of stroke or transient ischemic attack / Cochrane Database Syst Rev 4 google schola Hart RG / 1983 / Early recurrent embolism associated with nonvalvular atrial fibrillation : a retrospective study / Stroke 14:688~693 google schola D’Amelio M / 2014 / Early and late mortality of spontaneous hemorrhagic transformation of ischemic stroke / J Stroke Cerebrovasc Dis 23:649~654 google schola Hong KS / 2017 / Rivaroxaban vs warfarin sodium in the ultra-early period after atrial fibrillation-related mild ischemic stroke : a randomized clinical trial / JAMA Neurol 74:1206~1215 google schola

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