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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Despite recent advances in recanalization therapy, mechanical thrombectomy will never be a treatment for every ischemic stroke because access to mechanical thrombectomy is still limited in many countries. Moreover, many ischemic strokes are caused by occlusion of cerebral arteries that cannot be reached by intra-arterial catheters. Reperfusion using thrombolytic agents will therefore remain an important therapy for hyperacute ischemic stroke. However, thrombolytic drugs have shown limited efficacy and notable hemorrhagic complication rates, leaving room for improvement. A comprehensive understanding of basic and clinical research pipelines as well as the current status of thrombolytic therapy will help facilitate the development of new thrombolytics. Compared with alteplase, an ideal thrombolytic agent is expected to provide faster reperfusion in more patients; prevent re-occlusions; have higher fibrin specificity for selective activation of clot-bound plasminogen to decrease bleeding complications; be retained in the blood for a longer time to minimize dosage and allow administration as a single bolus; be more resistant to inhibitors; and be less antigenic for repetitive usage. Here, we review the currently available thrombolytics, strategies for the development of new clot-dissolving substances, and the assessment of thrombolytic efficacies in vitro and in vivo.
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참고문헌 (145)
참고문헌 신청
Fossum S / 1996 / Urokinase and non-urokinase fibrinolytic activity in protease-inhibitor-deprived plasma, assayed by a fibrin micro-plate method / Immunopharmacology 32:119~121
Sherry S / 1966 / Activity of plasmin and streptokinase-activator on substituted arginine and lysine esters / Thromb Diath Haemorrh 16:18~31
Niinobe M / 1980 / A sensitive colorimetric assay for various proteases using naphthyl ester derivatives as substrates / J Biochem 87:779~783
Barlow GH / 1980 / Plasma urokinase levels measured by chromogenic assay after infusions of tissue culture or urinary source material / Thromb Res 18:431~437
Kulseth MA / 1993 / A highly sensitive chromogenic microplate assay for quantification of rat and human plasminogen / Anal Biochem 210:314~317
Sherry S / 1966 / Activity of plasmin and streptokinase-activator on substituted arginine and lysine esters / Thromb Diath Haemorrh 16:18~31
Niinobe M / 1980 / A sensitive colorimetric assay for various proteases using naphthyl ester derivatives as substrates / J Biochem 87:779~783
Barlow GH / 1980 / Plasma urokinase levels measured by chromogenic assay after infusions of tissue culture or urinary source material / Thromb Res 18:431~437
Kulseth MA / 1993 / A highly sensitive chromogenic microplate assay for quantification of rat and human plasminogen / Anal Biochem 210:314~317
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