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논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2021.7
- 수록면
- 214 - 214 (1page)
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Ob/ob mouse is a mutant obese mouse that lacks the production of leptin and intake food excessively, and develops hepatic steatosis. Previous studies have showed that non-alcoholic steatohepatitis (NAFLD) patients showed decreased autophagy and defect of autophagy in hepatocytes is related with steatosis. In this study, we investigated whether impaired autophagy is involved in the development of fatty liver in ob/ob mouse. 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC) diet was fed to wild type (WT) mice and ob/ob mice for 2 weeks. H&E and Oil Red O staining and the level of triglyceride and cholesterol were evaluated. The genes related with autophagy was examined by Western blot and real-time RT-PCR. H&E and O ... 전체 초록 보기
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