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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2021.7
- 수록면
- 193 - 193 (1page)
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이 논문의 연구 히스토리 (2)
2021
Correlation of the distribution and residue pattern of the benzylpenicillin between kidney and urine in pigs injected intramuscularly
Sunjin Pa
,
k
,
Chung-Oui Hong
외 6명
한국실험동물학회 학술발표대회 논문집
2021.07
학술대회자료
The pharmacokinetics and residue distribution of benzylpenicillin in muscle and plasma of pigs injected intramuscularly
Sunjin Pa
,
k
,
Chung-Oui Hong
외 6명
한국실험동물학회 학술발표대회 논문집
2021.07
학술대회자료
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Benzylpenicillin, also known as penicillin G, is an antibiotic used to treat a number of bacterial infections and affects human health because of antibiotic resistance problems. It is very important to monitor residues repeatedly in muscle for food safety and find suitable fluids monitored instead of muscle before slaughter. Tissue distribution of benzylpenicillin was studied in pigs after triple intramuscular injection at 20mg/kg body weight with two days interval. The three kinds of samples as plasma, muscle at non-injection and injection site was collected from six pigs at various times after recommended and another 3 times the recommended dose administration. Benzylpenicillin concentrations were determined by high-performance liquid chromatography with tandem mass spectrometer following adequate pretreatment for various samples. The limits of quantification (LOQ) were 0.22 ng/mL for plasma and 0.16ng/g for muscle. A noncompartmental method was used to analyze plasma kinetics. Pharmacokinetic parameters in pla ... 전체 초록 보기
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