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논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2021.7
- 수록면
- 181 - 181 (1page)
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Non-alcoholic fatty liver disease (NAFLD) is leading cause of liver failure and its negative global impact on health is growing fast. Even though there has been many efforts and studies on treating NAFLD, there is still no FDA approved medical treatment for the disease. Recently, extensive research has been carried out on G-protein coupled receptors (GPCRs)’s role in wide range of metabolic processes. Adenosine and its receptors, Adenosine a3 receptor (A3AR) have the role of regulating energy metabolism and immune response in many different diseases. Mechanistically, the activation of A3AR inhibits cAMP-PKA pathway. However, the role of how biased agonist A3AR, FM101 regulates non-alcoholic steatohepatitis and mitochondrial function remains undefined. We first measured the mRNA expression of A3AR in three major cell types in NAFLD studies: hepatocyte (HPs), hepatic stellate cell (HSCs), and Kupffer cells (KCs). Interestingly, A3AR was mostly expressed in HSCs and KCs. Then, we used FM101 to check function of A3AR activ ... 전체 초록 보기
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