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논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2021.7
- 수록면
- 67 - 67 (1page)
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Mitochondria play essential roles in ATP synthesis, redox balance, metabolic flexibility, Ca<SUP>2+</SUP> sequestration, cell signaling, immunity, growth, development, and cell death. Accordingly, multifunctional and energetic mitochondria are critical for the resistance against various noxious stresses, diseases and senescence. Furthermore, attenuated autophagic degradation aggravates oxidative stress and mitochondrial dysfunction, all of which are known to constitute hallmarks of aging and age-related diseases. We have been investigated that oxidative stress impairs Ca<SUP>2+</SUP> homeostasis in mitochondria, endoplasmic reticulum and lysosome that deteriorates autophagic flux and cytotoxicity in chronic metabolic diseases. In addition, chronic mitochondrial oxidative stress participates in pathologic epithelial-mesenchymal transition and fibrosis of hepatic stellate cells, kidney podocytes, and retinal pigment epithelium. We have also identified the decisive actions of mitochondrial oxidative stress in high phosphate-induced insulin secretory defe ... 전체 초록 보기
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