지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.9
- 수록면
- 591 - 598 (8page)
이용수
초록· 키워드
오류제보하기
Background: Hematopoiesis is the production of blood cells from hematopoietic stem cells (HSCs) that reside in the bone marrow. Cyclophosphamide (CTX) is a chemotherapy drug that suppresses the immune system. Korean Red Ginseng (KRG) and Colla corii asini (CCA) have been traditionally used for boosting the immune system.
Methods: HSCs in the bone marrow, and immune cell subtype in splenocytes, PBMCs, and thymocytes were investigated. Serum levels of hematopoietic-related markers were analyzed using ELISA. Protein expression in spleen tissue was analyzed using western blot analysis. Hematoxylin & eosin staining in the femurs of mice were also conducted.
Results: The combination of KRG and CCA with a ratio of 3:2 increased HSCs, CD3 and CD8<SUP>+</SUP> T cells in the circulation, and CD3 T cells in the spleen. A ratio of 2:3 (KRG:CCA) increased the thymic regulatory T cells and recovered the CD3 T cells in the spleen and circulation while recovering proteins in the JAK-STAT pathway in the spleen. Overall, blood cell population and differentiating factors vital for cell differentiation were also significantly recovered by all combinations especially in ratios of 3:2 and 2:3.
Conclusion: A ratio of 3:2 (KRG:CCA) is the most ideal combination as it recovered the HSC population in the bone marrow of mice.
Methods: HSCs in the bone marrow, and immune cell subtype in splenocytes, PBMCs, and thymocytes were investigated. Serum levels of hematopoietic-related markers were analyzed using ELISA. Protein expression in spleen tissue was analyzed using western blot analysis. Hematoxylin & eosin staining in the femurs of mice were also conducted.
Results: The combination of KRG and CCA with a ratio of 3:2 increased HSCs, CD3 and CD8<SUP>+</SUP> T cells in the circulation, and CD3 T cells in the spleen. A ratio of 2:3 (KRG:CCA) increased the thymic regulatory T cells and recovered the CD3 T cells in the spleen and circulation while recovering proteins in the JAK-STAT pathway in the spleen. Overall, blood cell population and differentiating factors vital for cell differentiation were also significantly recovered by all combinations especially in ratios of 3:2 and 2:3.
Conclusion: A ratio of 3:2 (KRG:CCA) is the most ideal combination as it recovered the HSC population in the bone marrow of mice.
목차
abstract
1. Introduction
2. Materials and methods
3. Results
4. Discussion
References
참고문헌 (30)
참고문헌 신청
Orkin SH / 2008 / Hematopoiesis : an evolving paradigm for stem cell biology / Cell 132(4):631~644
Ahlmann M / 2016 / The effect of cyclophosphamide on the immune system : implications for clinical cancer therapy / Cancer Chemother Pharmacol 78(4):661~671
Lynch N / 2007 / Differences in perceived risks and benefits of herbal, overthe-counter conventional, and prescribed conventional, medicines, and the implications of this for the safe and effective use of herbal products / Complement Ther Medicine 15(2):84~91
Qiu J / 2007 / Traditional medicine : a culture in the balance / Nature 448(7150):126~128
Sun Hee Hyun / 2021 / Immuno-enhancement effects of Korean Red Ginseng in healthy adults: a randomized, double-blind, placebo-controlled trial / Journal of Ginseng Research 45(1):191~198
Ahlmann M / 2016 / The effect of cyclophosphamide on the immune system : implications for clinical cancer therapy / Cancer Chemother Pharmacol 78(4):661~671
Lynch N / 2007 / Differences in perceived risks and benefits of herbal, overthe-counter conventional, and prescribed conventional, medicines, and the implications of this for the safe and effective use of herbal products / Complement Ther Medicine 15(2):84~91
Qiu J / 2007 / Traditional medicine : a culture in the balance / Nature 448(7150):126~128
Sun Hee Hyun / 2021 / Immuno-enhancement effects of Korean Red Ginseng in healthy adults: a randomized, double-blind, placebo-controlled trial / Journal of Ginseng Research 45(1):191~198
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