지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 환경독성보건학회 Environmental Analysis Health and Toxicology Environmental Analysis Health and Toxicology Vol.36 No.2
- 발행연도
- 2021.6
- 수록면
- 19 - 29 (11page)
이용수
초록· 키워드
오류제보하기
Previous research studies on the toxicity of polyhexamethylene guanidine (PHMG) as a humidifier disinfectant majorly focused on lung fibrosis. Considering that disinfectants in humidifiers are released in aerosol form, the eyes are directly exposed and highly vulnerable to the detrimental effects of the PHMG. Therefore, in the present study we investigated the adverse effects of PHMG on the eyes; considering fibrosis as a manifestation of PHMG toxicity in the eye, we evaluated fibrosis-related biomarkers in cultured Statens Seruminstitut Rabbit Cornea (SIRC) cells. Cell viability was measured using 3-(4,5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assay, fibrosis-related biomarkers were evaluated through polymerase chain reaction (PCR) and immunoblotting, and oxidative stress was evaluated using 2’,7’-dichlorodihydrofluorescein diacetate (H₂DCFDA). Polyhexamethylene guanidine showed cytotoxicity in a time and concentration-dependent manner. Fibrosis related biomarkers including transforming growth factor-β (TGF-β), α-smooth muscle actin (α-SMA), matrix metalloproteinase (MMP), tissue inhibitor of metalloproteinase (TIMP) and hemeoxygenase-1 (HO-1) increased in both gene and protein levels. Oxidative stress also increased in the PHMG-treated cultured cells. The findings of the present study suggest that PHMG could cause toxicity in the eye as manifested by fibrosis.
목차
Abstract
Introduction
Materials and Methods
Results
Discussion
Conclusions
References
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
PHMG에 의한 토끼 안구 각막세포주에서의 섬유화 연구
환경독성보건학회 심포지엄 및 학술대회
2019 .10
-
An analysis of a humidifier disinfectant case from a toxicological perspective
Environmental Analysis Health and Toxicology
2016 .12
-
Integration of transcriptomics, proteomics and metabolomics identifies biomarkers for pulmonary injury by polyhexamethylene guanidine phosphate (PHMG-p), a humidifier disinfectant, in rats
환경독성보건학회 심포지엄 및 학술대회
2022 .10
-
Toxicogenomic study of PHMG-induced pulmonary toxicity in rats
환경독성보건학회 심포지엄 및 학술대회
2018 .06
-
Integration of transcriptomics and metabolomics identifies biomarkers for damage to polyhexamethylene guanidine phosphate (PHMG-p)-induced human alveolar epithelial A549 cells
환경독성보건학회 심포지엄 및 학술대회
2022 .05
-
Respiratory toxicity of polyhexamethylene guanidine phosphate exposure in zebrafish
한국실험동물학회 학술발표대회 논문집
2017 .08
-
Study of lung and liver damage mechanism of polyhexamethylene guanidine-phosphate (PHMG-P)
환경독성보건학회 심포지엄 및 학술대회
2019 .10
-
Effect of PHMG-P on TGF-β mediated signaling pathways in animal models
환경독성보건학회 심포지엄 및 학술대회
2019 .10
-
Effects of polyhexamethylene guanidine-phosphate and polyhexamethylene biguanide on epithelial-mesenchymal transtion in A549 cell line
환경독성보건학회 심포지엄 및 학술대회
2016 .06
-
PHMG-p에 의한 혈소판에서의 혈액응고 활성 촉진
환경독성보건학회 심포지엄 및 학술대회
2023 .11
-
The fibrogenic effects of EV miR-451a from bronchial epithelial cells injured by PHMG-phosphate
환경독성보건학회 심포지엄 및 학술대회
2019 .10
-
Effects of PHMG, a humidifier disinfectant, on eye-dryness using LC-MS-based metabolite profiling
환경독성보건학회 심포지엄 및 학술대회
2022 .05
-
H-NMR based metabolomics study of PHMG-p-induced cytotoxicity in human alveolar epithelial A549 cells
환경독성보건학회 심포지엄 및 학술대회
2021 .10
-
Evaluation of the effects of intratracheal instillation of polyhexamethylene guanidine-phosphate (PHMG-p) on pregnancy and fetal outcomes in rats
환경독성보건학회 심포지엄 및 학술대회
2023 .11
-
Polyhexamethylene guanidine phosphate exacerbates asthmatic responses in ovalbumin-sensitized mouse and 3D cell models
환경독성보건학회 심포지엄 및 학술대회
2021 .05
-
¹H-NMR-based toxicometabolomics study of PHMG-p-induced pulmonary damage in mice
환경독성보건학회 심포지엄 및 학술대회
2019 .10
-
Effect of PHMG-p on TGF-β mediated signaling pathways in vivo and in vitro
환경독성보건학회 심포지엄 및 학술대회
2019 .04
-
Phosphatidylserine externalization in erythrocytes induced by polyhexamethylene guanidine phosphate promotes venous thrombus formation in a rat model
한국실험동물학회 학술발표대회 논문집
2025 .02
-
가습기살균제 Polyhexamethylene Guanidine (PHMG) 노출에 의한 제브라피쉬 행동영향 평가
환경독성보건학회 심포지엄 및 학술대회
2023 .05
-
Therapeutic effects of Shibashin Misena® against fine-dust-induced pulmonary disorders in mice
한국실험동물학회 학술발표대회 논문집
2020 .02
이 논문의 저자 정보
최근 본 자료
댓글(0)
0