지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2021.5
- 수록면
- 191 - 191 (1page)
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Purpose
We investigated the anticancer effect and systemic effect of the atelocollagen (AC) patch coated nucleoline-aptamer-conjugated Gemcitabine (IO401 patch) by directly implanting to the tumor cell in pancreatic cancer patient-derived xenograft (PDX) model to purpose a future potential adjuvant surgical strategy during curative pancreatic resection for pancreatic cancer.
Methods
Pancreatic cancer PDX model was established. Animals were grouped randomly (7 mice per group) into three types of patch transplantation groups: G1= Null AC patch, G2= Gemcitabine AC patch, G3= IO401 patch. Tumor volume (length x width2, mm3), Tumor weight (mg), and Tumor inhibition rate [1-(Ti-To) / (average tumor volume of group)) x 100, Ti=endpoint tumor volume, To=start tumor volume] were calculated. Anticancer therapy-related toxicity was evaluated by hematologic and histol^_@span style=color:#999999 ^_# ... ^_@/span^_#^_@a href=javascript:; onclick=onClickReadNode('NODE10577857');fn_statistics('Z354','null','null'); style='color:#999999;font-size:14px;text-decoration:underline;' ^_#전체 초록 보기^_@/a^_#
We investigated the anticancer effect and systemic effect of the atelocollagen (AC) patch coated nucleoline-aptamer-conjugated Gemcitabine (IO401 patch) by directly implanting to the tumor cell in pancreatic cancer patient-derived xenograft (PDX) model to purpose a future potential adjuvant surgical strategy during curative pancreatic resection for pancreatic cancer.
Methods
Pancreatic cancer PDX model was established. Animals were grouped randomly (7 mice per group) into three types of patch transplantation groups: G1= Null AC patch, G2= Gemcitabine AC patch, G3= IO401 patch. Tumor volume (length x width2, mm3), Tumor weight (mg), and Tumor inhibition rate [1-(Ti-To) / (average tumor volume of group)) x 100, Ti=endpoint tumor volume, To=start tumor volume] were calculated. Anticancer therapy-related toxicity was evaluated by hematologic and histol^_@span style=color:#999999 ^_# ... ^_@/span^_#^_@a href=javascript:; onclick=onClickReadNode('NODE10577857');fn_statistics('Z354','null','null'); style='color:#999999;font-size:14px;text-decoration:underline;' ^_#전체 초록 보기^_@/a^_#
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