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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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초록· 키워드
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Multidrug-resistant strain of Acinetobacter baumannii (MDRAB) is an emerging pathogen in health care facilities, preventing MDRAB is a public health concern. We conducted this experiment on a clinical isolate of A. baumannii with two main goals: the role of the efflux pump system in the stress provision of carbapenem and the response to the transcription level of the efflux pump gene. A total of 34 strains of A. baumannii was isolated from the Yangsan Hospital of Pusan National University. First, when we compared and observed the expression of the efflux pump gene and antibacterial resistance to carbapenem, a strong correlation was observed between carbapenem resistance and overexpression of adeB (P=0.0056). Second, a correlation between the efflux pump and concentration gradient and tolerance to carbapenem stress at the AdeABC efflux pump genes transcription level was confirmed. Our results revealed that the expression of the AdeABC efflux pump is an important resistance determinant in obtaining antibiotic resistance of the carbapenem group in A. baumannii.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (38)
참고문헌 신청
Amabile-Cuevas CF / 2010 / Fluoroquinolone resistance in clinical and environmental isolates of Escherichia coli in Mexico City / J Appl Microbiol 108:158~162
배일권 / 2012 / Carbapenem 내성 Acinetobacter baumannii / Annals of Clinical Microbiology 15(1):1~8
Batirel A / 2014 / Comparison of colistin-carbapenem, colistin-sulbactam, and colistin plus other antibacterial agents for the treatment of extremely drug-resistant Acinetobacter baumannii bloodstream infections / Eur J Clin Microbiol Infect Dis 33:1311~1322
Baugh S / 2014 / Inhibition of multidrug efflux as a strategy to prevent biofilm formation / J Antimicrob Chemother 69:673~681
Blair JM / 2015 / Molecular mechanisms of antibiotic resistance / Nat Rev Microbiol 13:42~51
배일권 / 2012 / Carbapenem 내성 Acinetobacter baumannii / Annals of Clinical Microbiology 15(1):1~8
Batirel A / 2014 / Comparison of colistin-carbapenem, colistin-sulbactam, and colistin plus other antibacterial agents for the treatment of extremely drug-resistant Acinetobacter baumannii bloodstream infections / Eur J Clin Microbiol Infect Dis 33:1311~1322
Baugh S / 2014 / Inhibition of multidrug efflux as a strategy to prevent biofilm formation / J Antimicrob Chemother 69:673~681
Blair JM / 2015 / Molecular mechanisms of antibiotic resistance / Nat Rev Microbiol 13:42~51
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RND efflux pump systems in Acinetobacter, with special emphasis on their role in quorum sensing
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ISAba15 Inserted into Outer Membrane Protein Gene carO in Acinetobacter baumannii
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Optimizing Treatment for Carbapenem-Resistant Acinetobacter baumannii Complex Infections: A Review of Current Evidence
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Prediction of Putative Resistance Islands in a Carbapenem-Resistant Acinetobacter baumannii Global Clone 2 Clinical Isolate
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Overexpression of Efflux Pump in Multiresistant Pseudomonas aeruginosa: How You Will Discover and Treat It?
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The Nod2 in essential for host immune defense against Acinetobacter baumannii infection
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Acinetobacter baumannii 임상분리주의 다약제 내성에 대한 adeIJK 유출펌프 유전자의 역할
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In Vitro Synergistic Effects of Antimicrobial Combinations on Extensively Drug-Resistant Pseudomonas aeruginosa and Acinetobacter baumannii Isolates
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Increasing Resistance to Extended-Spectrum Cephalosporins, Fluoroquinolone, and Carbapenem in Gram-Negative Bacilli and the Emergence of Carbapenem Non-Susceptibility in Klebsiella pneumoniae: Analysis of Korean Antimicrobial Resistance Monitoring System (KARMS) Data From 2013 to 2015
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UCI(KEPA) : I410-ECN-0101-2021-510-001864830