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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.4
- 수록면
- 64 - 71 (8page)
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초록· 키워드
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Patients with severe coronavirus disease 2019 (COVID-19) demonstrate dysregulated immune responses including exacerbated neutrophil functions. Massive neutrophil infiltrations accompanying neutrophil extracellular trap (NET) formations are also observed in patients with severe COVID-19. However, the mechanism underlying severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-induced NET formation has not yet been elucidated. Here we show that 2 viral proteins encoded by SARS-CoV-2, the nucleocapsid protein and the whole spike protein, induce NET formation from neutrophils. NET formation was ROS-independent and was completely inhibited by the spleen tyrosine kinase inhibition. The inhibition of p38 MAPK, protein kinase C, and JNK signaling pathways also inhibited viral protein-induced NET formation. Our findings demonstrate one method by which SARS-CoV-2 evades innate immunity and provide a potential target for therapeutics to treat patients with severe COVID-19.
목차
ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS AND DISCUSSION
REFERENCES
참고문헌 (32)
참고문헌 신청
Mehta P / 2020 / Manson JJ; HLH Across Speciality Collaboration, UK. COVID-19: consider cytokine storm syndromes and immunosuppression / Lancet 395:1033~1034
Tay MZ / 2020 / The trinity of COVID-19 : immunity, inflammation and intervention / Nat Rev Immunol 20:363~374
Vabret N / 2020 / Immunology of COVID-19 : current state of the science / Immunity 52:910~941
Barnes BJ / 2020 / Targeting potential drivers of COVID-19 : neutrophil extracellular traps / J Exp Med 217:e20200652
Fox SE / 2020 / Pulmonary and cardiac pathology in African American patients with COVID-19 : an autopsy series from New Orleans / Lancet Respir Med 8:681~686
Tay MZ / 2020 / The trinity of COVID-19 : immunity, inflammation and intervention / Nat Rev Immunol 20:363~374
Vabret N / 2020 / Immunology of COVID-19 : current state of the science / Immunity 52:910~941
Barnes BJ / 2020 / Targeting potential drivers of COVID-19 : neutrophil extracellular traps / J Exp Med 217:e20200652
Fox SE / 2020 / Pulmonary and cardiac pathology in African American patients with COVID-19 : an autopsy series from New Orleans / Lancet Respir Med 8:681~686
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UCI(KEPA) : I410-ECN-0101-2021-517-001751675