지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한외과학회 Annals of Surgical Treatment and Research Annals of Surgical Treatment and Research Vol.100 No.6
- 발행연도
- 2021.6
- 수록면
- 356 - 363 (8page)
이용수
초록· 키워드
오류제보하기
Purpose: The aim of this study was to assess the efficacy of intravenous hydrocortisone, ascorbic acid, and thiamine (HAT) combination therapy in complicated intraabdominal infection (cIAI) patients with septic shock.
Methods: This was a single-center, retrospective before-after clinical study comparing clinical outcomes of cIAI patients with septic shock treated with HAT in a surgical intensive care unit (ICU). Delta modified sequential organ failure assessment (mSOFA) scores were evaluated to assess recovery of organ dysfunction. Additional outcomes included procalcitonin level change, daily vasopressor dosage, mean number of days free of mechanical ventilation in 28 days, and renal replacement therapy days.
Results: The delta mSOFA score (ICU admission mSOFA score minus 7th-day mSOFA score) was significantly higher in the HAT group than in the control group on the 7th day (2.30 vs. –0.90, P = 0.003). The median 7-day change in procalcitonin score was higher in the control group than in the HAT group (5.94 vs. 10.72, P = 0.041). The difference in vasopressor score between the 1st day and the 4th day was significantly higher in the HAT group (17.63 vs. 9.91, P = 0.005).
Conclusion: In our study of cIAI in patients with septic shock, administration of HAT therapy may improve the recovery from organ dysfunction.
Methods: This was a single-center, retrospective before-after clinical study comparing clinical outcomes of cIAI patients with septic shock treated with HAT in a surgical intensive care unit (ICU). Delta modified sequential organ failure assessment (mSOFA) scores were evaluated to assess recovery of organ dysfunction. Additional outcomes included procalcitonin level change, daily vasopressor dosage, mean number of days free of mechanical ventilation in 28 days, and renal replacement therapy days.
Results: The delta mSOFA score (ICU admission mSOFA score minus 7th-day mSOFA score) was significantly higher in the HAT group than in the control group on the 7th day (2.30 vs. –0.90, P = 0.003). The median 7-day change in procalcitonin score was higher in the control group than in the HAT group (5.94 vs. 10.72, P = 0.041). The difference in vasopressor score between the 1st day and the 4th day was significantly higher in the HAT group (17.63 vs. 9.91, P = 0.005).
Conclusion: In our study of cIAI in patients with septic shock, administration of HAT therapy may improve the recovery from organ dysfunction.
목차
INTRODUCTION
METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (21)
참고문헌 신청
Walkey AJ / 2015 / Trends in sepsis and infection sources in the United States. a population-based study / Ann Am Thorac Soc 12:216~220
Cohen J / 2015 / Sepsis : a roadmap for future research / Lancet Infect Dis 15:581~614
Brun-Buisson C / 1995 / Incidence, risk factors, and outcome of severe sepsis and septic shock in adults. A multicenter prospective study in intensive care units / JAMA 274:968~974
최원호 / 2009 / 복강 내 감염에 의한 패혈증으로 수술 받은 환자에 있어서Sequential Organ Failure Assessment (SOFA) Score의 유용성 / Annals of Surgical Treatment and Research 76(5):273~278
Mulier S / 2003 / Factors affecting mortality in generalized postoperative peritonitis : multivariate analysis in 96patients / World J Surg 27:379~384
Cohen J / 2015 / Sepsis : a roadmap for future research / Lancet Infect Dis 15:581~614
Brun-Buisson C / 1995 / Incidence, risk factors, and outcome of severe sepsis and septic shock in adults. A multicenter prospective study in intensive care units / JAMA 274:968~974
최원호 / 2009 / 복강 내 감염에 의한 패혈증으로 수술 받은 환자에 있어서Sequential Organ Failure Assessment (SOFA) Score의 유용성 / Annals of Surgical Treatment and Research 76(5):273~278
Mulier S / 2003 / Factors affecting mortality in generalized postoperative peritonitis : multivariate analysis in 96patients / World J Surg 27:379~384
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