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논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2021.4
- 수록면
- 561 - 561 (1page)
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We report fermentative production of 5-hydroxyvaleric acid (5-HV), an important C5 platform chemical that can work as a versatile building block, from glucose as a sole carbon source using metabolically engineered Corynebacterium glutamicum. First, an artificial 5-HV biosynthesis pathway that initiates with the first three reaction steps of an L-lysine catabolic pathway encoded by Pseudomonas putida davTBA genes along with a subsequent intracellular reduction step was constructed in C. glutamicum. To efficiently obtain 5-HV, various aldehyde reductase candidates which might mediate intracellular reduction of glutarate semialdehyde to 5-HV were examined: CpnD from Clostridium aminovalericu ... 전체 초록 보기
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