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논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2021.4
- 수록면
- 256 - 256 (1page)
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Caspase-3 is a proteolytic enzyme that plays an essential role in cell apoptosis. Since the expression levels of caspase-3 in cells are low, it is important to use sensitive biosensor for the detection of proteolytic enzymes. In this study, we have developed bifunctional Au nanoparticles (AuNPs) to create highly sensitive metal-enhanced-fluorescence (MEF)-based biosensor for detection of caspase-3. In this biosensor, both single-stranded DNA (ssDNA) and a peptide are linking between AuNPs and the fluorophore. Once a caspase-3 cuts the peptide, the ssDNA is able to maintain an optimal distance for the MEF and thu^_@span style=color:#999999 ^_# ... ^_@/span^_#^_@a href=javascript:; onclick=onClickReadNode('NODE10554489');fn_statistics('Z354','null','null'); style='color:#999999;font-size:14px;text-decoration:underline;' ^_#전체 초록 보기^_@/a^_#
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