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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Hypertension (HTN) is one of the cardiovascular disease risk factors. Peroxisome proliferator-activated receptor γ coactivator 1 alpha (PPARGC1A) is involved in a master modulator of mitochondrial biogenesis, and pulmonary arterial hypertension. In this study, we report results of PPARGC1A were associated with hypertension and its intermediate phenotype of systolic (SBP) and diastolic blood pressure (DBP) in the Korean population. In detail, identifying a susceptibility locus, 3 SNPs for HTN, 2 SNPs for SBP, 3 SNPs for DBP at P<0.05. Among them, rs1472095 in PPARGC1A gene statistically demonstrated one of the significant correlations with Hypertension (P-value=0.00359, OR=0.8, 95% CI=0.68~0.93). The minor allele (T) of PPARGC1A was statistically associated with the increased value of DBP, SBP, and the increase risk of hypertension. We aim to manifest a significant association between genetic variant in PPARGC1A and hypertension. This finding suggested that association of PPARGC1A genetic polymorphism and HTN accelerates our understanding of blood pressure control and underlines potential drug targets for treatment of hypertension.
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REFERENCES
참고문헌 (23)
참고문헌 신청
Ahmetov II / 2015 / Current Progress in Sports Genomics / Adv Clin Chem 70:247~314
Cabrera CP / 2019 / Over 1000 genetic loci influencing blood pressure with multiple systems and tissues implicated / Hum Mol Genet 28:R151~R161
Carretero OA / 2000 / Essential hypertension. Part I: definition and etiology / Circulation 101:329~335
Cho YS / 2009 / A largescale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits / Nat Genet 41:527~534
El Rouby N / 2019 / Genome-wide association analysis of common genetic variants of resistant hypertension / Pharmacogenomics J 19:295~304
Cabrera CP / 2019 / Over 1000 genetic loci influencing blood pressure with multiple systems and tissues implicated / Hum Mol Genet 28:R151~R161
Carretero OA / 2000 / Essential hypertension. Part I: definition and etiology / Circulation 101:329~335
Cho YS / 2009 / A largescale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits / Nat Genet 41:527~534
El Rouby N / 2019 / Genome-wide association analysis of common genetic variants of resistant hypertension / Pharmacogenomics J 19:295~304
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