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논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2021.1
- 수록면
- 106 - 106 (1page)
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Oligo(2-(2-ethoxy) ethoxyethyl guanidinium chloride (PGH, CAS No. 374572-91-5) is a polymeric biocide with a guanidine group. It is a causative agents of the tragic humidifier disinfectant incident, which had caused death of over 179 people in Korea. Few studies have assessed the toxicity of PGH. The aim of this study was to assess and compare the toxic effects of PGH and PHMG, another guanidine biocide, when they are directly exposed to the lungs. PGH (1.5 mg/kg) or PHMG (0.6 mg/kg) was instilled intratracheally to mice once or three times every 4 days. Cytokine levels were quantified and a histopathological examination was performed. To evaluate the mechanism of toxic effect of PGH, cell viability and cytokine production induced by PGH or PHMG-P were measured in the presence or absence of anionic material in cells. ... 전체 초록 보기
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