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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2021.1
- 수록면
- 100 - 100 (1page)
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Introduction: Postoperative cognitive dysfunction (POCD) following surgery and anesthesia is a common and severe complication, especially in elderly patients. Also, preexisting cognitive impairment may impart a susceptibility to further cognitive dysfunction not yet been completely elucidated. Thus, we hypothesized that the specific impact of anesthesia on individuals with preclinical Alzheimer’s disease (AD) may make individuals more susceptible to increase the risk of progression of cognitive impairment. The aim of this study was to compare the cognitive impairment between adult and preclinical AD mice model after propofol anesthesia and surgery.
Methods: We conducted abdominal surgery in cognitively presymptomatic (5-month-old) sporadic AD (ApoE4-KI) and age-matched control (C57BL/6J) male mice under propofol anesthesia (170mg/kg) via retro-orbital injections during two hours. Morris water (MWM) and Y maze testing was conducted 2day before and 2, 4, 7 days after surgery. Mean escape latencies and zone alteration percentage were recorded as a major outcome. Neuron apoptosis was evaluated in hippocampal sections using the terminal dUTP nick-end labeling (TUNEL) assay. Amyloid beta (Aβ) level wa ... 전체 초록 보기
Methods: We conducted abdominal surgery in cognitively presymptomatic (5-month-old) sporadic AD (ApoE4-KI) and age-matched control (C57BL/6J) male mice under propofol anesthesia (170mg/kg) via retro-orbital injections during two hours. Morris water (MWM) and Y maze testing was conducted 2day before and 2, 4, 7 days after surgery. Mean escape latencies and zone alteration percentage were recorded as a major outcome. Neuron apoptosis was evaluated in hippocampal sections using the terminal dUTP nick-end labeling (TUNEL) assay. Amyloid beta (Aβ) level wa ... 전체 초록 보기
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UCI(KEPA) : I410-ECN-0101-2021-528-001570019