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Pharmacological research based on primates
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논문 기본 정보

Type
Proceeding
Author
Dohyun Ignacio Lee (Osong Medical Innovation Foundation)
Journal
Korean Association for Laboratory Animal Science 한국실험동물학회 학술발표대회 논문집 2021 KALAS Winter Symposium
Published
2021.1
Pages
39 - 39 (1page)

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Pharmacological research based on primates
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Selection of relevant animal species is essential in preclinical research for new drug development. For preclinical studies of therapeutic monoclonal antibodies (mAbs), relevant animal species are those express desired epitope and demonstrate a similar cross-reactivity profile as for human. Primates are evolutionary closer to humans than other animal species. Especially, cynomolgus monkey cross-react with therapeutic mAb much higher than other animal species (rodents, rabbit, guinea pig, dogs and pigs) commonly used in preclinical studies such as absorption, distribution, metabolism and excretion (ADME), efficacy, and toxicity studies in development for mAb drugs. According to previous reports, similarity of Fc receptor (FcRn) for ... View All
#Cynomolgus monkeys #Therapeutic monoclonal antibodies #Pharmacokinetic #Fc receptor #New drug development

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