지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.12
- 수록면
- 319 - 329 (11page)
- DOI
- 10.7841/ksbbj.2020.35.4.319
이용수
초록· 키워드
오류제보하기
Foot-and-mouth disease (FMD) is a highly contagious viral disease susceptible to cloven- hoofed animals such as cattle, pig and goat, consequently exerting a bad influence on the livestock industry. Although various FMD vaccines have been developed for several decades, the efficacy of current FMD vaccines is restrictive because of the FMD virus (FMDV) diversity. The aim of this study was to determine whether the FMD virus (FMDV) serotype A and O epitope recombinant protein vaccine shows protective effects in a FMD animal model using pigs. To manufacture the recombinant protein vaccine, three or six replicates of VP1 epitopes of A/Pocheon/SKR/2010 and O/Andong/SKR/2010 FMDV strains were used and coupled with a swine immunoglobulin G heavy-chain constant region. Pigs were vaccinated twice (interval of 4 weeks) intramuscularly and examined the serum titers of FMDV specific antibody and neutralization antibody. After FMDV challenge, the gross lesions and clinical signs in FMD were assessed, and the viremia was measured by RTPCR assay using oral swabs. In the field experiment using pigs, FMDV-specific antibodies were markedly induced in the sera of FMD vaccine-immunized pigs. In addition, produced antibodies dramatically inhibited FMDV in vitro. Moreover, from challenge test in pigs to test the potency of FMD vaccine, at least more than 93% of vaccinated pigs were clearly protected from FMD. Taken together, these results strongly demonstrate that FMDV bivalent epitope-constituted recombinant protein vaccine shows obviously protective effects against two different serotypes (A, O) of FMDV.
목차
Abstract
1. INTRODUCTION
2. MATERIALS AND METHODS
3. RESULTS
4. DISCUSSION
5. CONCLUSION
REFERENCES
참고문헌 (42)
참고문헌 신청
Grubman, M. J. / 2004 / Foot-and-mouth disease / Clin Microbiol Rev 17:465~493
Davies, G. / 2002 / Foot and mouth disease / Res Vet Sci 73:195~199
Sørensen, J. H. / 2000 / An integrated model to predict the atmospheric spread of foot-and-mouth disease virus / Epidemiol Infect 124:577~590
유한상 / 2011 / 구제역 : 원인체의 특성, 국내, 외 발생 상황 및 예방대책 / Infection and Chemotherapy 43(2):178~185
Donaldson, A. L. / 2002 / Predicting the spread of foot and mouth disease by airborne virus / Int. Epizoot 21:569~575
Davies, G. / 2002 / Foot and mouth disease / Res Vet Sci 73:195~199
Sørensen, J. H. / 2000 / An integrated model to predict the atmospheric spread of foot-and-mouth disease virus / Epidemiol Infect 124:577~590
유한상 / 2011 / 구제역 : 원인체의 특성, 국내, 외 발생 상황 및 예방대책 / Infection and Chemotherapy 43(2):178~185
Donaldson, A. L. / 2002 / Predicting the spread of foot and mouth disease by airborne virus / Int. Epizoot 21:569~575
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