지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한외과학회 Annals of Surgical Treatment and Research Annals of Surgical Treatment and Research Vol.99 No.6
- 발행연도
- 2020.12
- 수록면
- 315 - 319 (5page)
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초록· 키워드
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Purpose: Paragangliomas (PGL) are rare neuroendocrine tumors derived from chromaffin cells of the autonomic nervous system. We aim to describe our experience and the long-term outcome of abdominal PGL over the last decade.
Methods: A retrospective review of patients diagnosed with PGL in our hospital between November 2005 and June 2017 was conducted. All nonabdominal PGL were excluded and the clinicopathological features and long-term outcomes of the patients were analyzed.
Results: A total of 46 patients were diagnosed with abdominal PGL. The average age of diagnosis was 55.4 years and there was no sex predilection. The average tumor size was 5.85 cm and they were predominantly located in the infrarenal position (50%). The mean follow-up period was 42 months (range, 1.8–252 months). All patients with metastases had Pheochromocytoma of the Adrenal Gland Scaled Score (PASS) of ≥4. One patient presented with synchronous metastases while 2 developed local recurrence and distant metastases. One presented with only local recurrence. One patient died 5 years after diagnosis.
Conclusion: Abdominal PGL is a rare tumor with excellent long-term prognosis. Recurrence although uncommon, can occur decades after initial diagnosis. Long-term follow-up is therefore recommended for all patients with PGL, especially in patients with PASS of ≥4.
Methods: A retrospective review of patients diagnosed with PGL in our hospital between November 2005 and June 2017 was conducted. All nonabdominal PGL were excluded and the clinicopathological features and long-term outcomes of the patients were analyzed.
Results: A total of 46 patients were diagnosed with abdominal PGL. The average age of diagnosis was 55.4 years and there was no sex predilection. The average tumor size was 5.85 cm and they were predominantly located in the infrarenal position (50%). The mean follow-up period was 42 months (range, 1.8–252 months). All patients with metastases had Pheochromocytoma of the Adrenal Gland Scaled Score (PASS) of ≥4. One patient presented with synchronous metastases while 2 developed local recurrence and distant metastases. One presented with only local recurrence. One patient died 5 years after diagnosis.
Conclusion: Abdominal PGL is a rare tumor with excellent long-term prognosis. Recurrence although uncommon, can occur decades after initial diagnosis. Long-term follow-up is therefore recommended for all patients with PGL, especially in patients with PASS of ≥4.
목차
INTRODUCTION
METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (17)
참고문헌 신청
Pillai S / 2016 / Updates on the genetics and the clinical impacts on phaeochromocytoma and paraganglioma in the new era / Crit Rev Oncol Hematol 100:190~208
Lenders JW / 2014 / Pheochromocytoma and paraganglioma : an Endocrine Society clinical practice guideline / J Clin Endocrinol Metab 99:1915~1942
Lenders JW / 2005 / Phaeochromocytoma / Lancet 366:665~675
Chen H / 2010 / The North American Neuroendocrine Tumor Society consensus guideline for the diagnosis and management of neuroendocrine tumors : pheochromocytoma, paraganglioma, and medullary thyroid cancer / Pancreas 39:775~783
Galan SR / 2013 / Genetics and molecular pathogenesis of pheochromocytoma and paraganglioma / Clin Endocrinol(Oxf) 78:165~175
Lenders JW / 2014 / Pheochromocytoma and paraganglioma : an Endocrine Society clinical practice guideline / J Clin Endocrinol Metab 99:1915~1942
Lenders JW / 2005 / Phaeochromocytoma / Lancet 366:665~675
Chen H / 2010 / The North American Neuroendocrine Tumor Society consensus guideline for the diagnosis and management of neuroendocrine tumors : pheochromocytoma, paraganglioma, and medullary thyroid cancer / Pancreas 39:775~783
Galan SR / 2013 / Genetics and molecular pathogenesis of pheochromocytoma and paraganglioma / Clin Endocrinol(Oxf) 78:165~175
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UCI(KEPA) : I410-ECN-0101-2021-514-000053037