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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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초록· 키워드
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Objectives: This study was done to look into whether Nrf2 take some role in the anti-lipogenic effect of kaurenoic acid in a nonalcoholic fatty liver disease (NAFLD) cellular model.
Materials and Methods: We measured the effect of kaurenoic acid on intracellular steatosis and Nrf2 activation. Next, the effect of kaurenoic acid on SREBP-1c and some lipogenic genes in palmitate treated HepG2 cells with or without Nrf2 silencing.
Results: The increased SREBP-1c expression was significantly decreased by concomitant kaurenoic acid treatment in non-targeting negative control siRNA transfected HepG2 cells. However, kaurenoic acid did not significantly inhibited increased SREBP-1c level in Nrf2 specific siRNA transfected HepG2 cells
Conclusions: Kaurenoic acid has a potential to activate Nrf2, which may suppress SREBP-1c mediated intracellular steatosis in HepG2 cells.
Materials and Methods: We measured the effect of kaurenoic acid on intracellular steatosis and Nrf2 activation. Next, the effect of kaurenoic acid on SREBP-1c and some lipogenic genes in palmitate treated HepG2 cells with or without Nrf2 silencing.
Results: The increased SREBP-1c expression was significantly decreased by concomitant kaurenoic acid treatment in non-targeting negative control siRNA transfected HepG2 cells. However, kaurenoic acid did not significantly inhibited increased SREBP-1c level in Nrf2 specific siRNA transfected HepG2 cells
Conclusions: Kaurenoic acid has a potential to activate Nrf2, which may suppress SREBP-1c mediated intracellular steatosis in HepG2 cells.
목차
Introduction
Materials and Methods
Results
Discussion
Conclusions
References
참고문헌 (20)
참고문헌 신청
Sourianarayanane A / 2013 / Management of non-alcoholic fatty liver disease / Minerva Gastroenterol Dietol 59(1):69~87
Kim CH / 2008 / Nonalcoholic fatty liver disease : a manifestation of the metabolic syndrome / Cleve Clin J Med 75(10):721~728
Younossi ZM / 2016 / Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes / Hepatology 64(1):73~84
Bryan HK / 2013 / The Nrf2 cell defence pathway : Keap1-dependent and-independent mechanisms of regulation / Biochem Pharmacol 85(6):705~717
Bataille AM / 2012 / Nrf2 : a potential target for new therapeutics in liver disease / Clin Pharmacol Ther 92(3):340~348
Kim CH / 2008 / Nonalcoholic fatty liver disease : a manifestation of the metabolic syndrome / Cleve Clin J Med 75(10):721~728
Younossi ZM / 2016 / Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes / Hepatology 64(1):73~84
Bryan HK / 2013 / The Nrf2 cell defence pathway : Keap1-dependent and-independent mechanisms of regulation / Biochem Pharmacol 85(6):705~717
Bataille AM / 2012 / Nrf2 : a potential target for new therapeutics in liver disease / Clin Pharmacol Ther 92(3):340~348
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UCI(KEPA) : I410-ECN-0101-2021-519-000053643