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논문 기본 정보

자료유형
학술저널
저자정보
Sarker, Satyajit Dey (Pharmaceutical Biotechnology Research Group, School of Biomedical Sciences, University of Ulster at Coleraine) Kumarasamy, Yashodharan (School of Pharmacy, The Robert Gordon University) Shoeb, Mohammad (School of Pharmacy, The Robert Gordon University) Celik, Sezgin (Department of Biology, Faculty of Science and Literature, 18 Mart University) Eucel, Ersin (Department of Biology, Faculty of Science, Anadolu University) Middleton, Moira (School of Pharmacy, The Robert Gordon University) Nahar, Lutfun (School of Life Sciences, The Robert Gordon University)
저널정보
경희한의학연구센터 Oriental pharmacy and experimental medicine Oriental pharmacy and experimental medicine 제5권 제3호
발행연도
2005.1
수록면
246 - 250 (5page)

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A number of species of the genus Centaurea (Family: Asteraceae), distributed in various parts of Asia, Europe and North America, have been used in traditional plant-based medicine and reported to possess various medicinal properties. As part of our continuing evaluation of plants from the genus Centaurea for their phytochemistry and biological activities, the dichloromethane (DCM) and methanol (MeOH) extracts of the seeds of Turkish Centaurea species, C. bornmuelleri, C. huber-morathii and C. schiskinii, were screened for antioxidant and antibacterial activities. Among the three species, C. huber-morathii displayed the most prominent antibacterial activity. Both the MeOH and DCM extracts of this plant showed activity against Citrobacter freundii, Enterococcus faecalis and Salmonella goldcoast with the MIC values within the range of $1\;{\times}\;10^{-2}\;to\;1\;{\times}\;10^{-3}\;mg/ml$. The MeOH extract of C schiskinii showed activity $(MIC\;=\;1\;{\times}\;10^{-1}\;mg/ml)$ against Citrobacter freundii and Staphylococcus aureus. While the DCM extract of C. bornmuelleri was only active against Staphylococcus aureus $(MIC\;=1\;{\times}\;10^{-2}\;mg/ml)$, the MeOH extract did not show any inhibitory activity at test concentrations. The DCM and MeOH extracts of all three species demonstrated good degree of antioxidant property in the DPPH assay with the $RC_{50}$ values ranging from $72\;{\times}\;10^{-2}\;to\;31{\times}\;10^{-3}\;mg/ml$. Among these extracts, the MeOH extract of C. hubermorathii was the most active antioxidant extract $(MlC\;=\;31\;{\times}\;10^{-3}\;mg/ml)$.

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