지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Silybin is known to be a major active flavonoid component isolated from Silybum marianum, a hepatoprotective medicinal plant. In this study, we examined the immunomodulatory role of silybin on T cell and macrophage-mediated immune responses. To do this, the proliferation of splenic lymphocytes and CD8+ CTLL-2 cells under mitogenic stimulation with lipopolysaccharide (LPS), concanavalin (Con) A and interleukin (IL)-2 and the production of $TNF-{\alpha}$ and NO from LPS- and $IFN-{\gamma}$-activated macrophages was evaluated under silybin treatment. The mitogenic proliferation of splenic lymphocytes induced by LPS and Con A was strongly diminished by silybin in a dose-dependent manner. Moreover, the proliferation of CD8+ CTLL-2 cells was also negatively modulated by the compound. In contrast, silybin did not strongly suppress the proliferation of normal splenocytes and T cell line Sup-T1 cells, indicating that the inhibitory effect of silybin may be due to blocking only mitogenic responses of splenic lymphocytes. In addition, silybin inhibited $TNF-{\alpha}$ production in LPS-stimulated RAW264.7 cells. Effect of silybin however was distinct, according to NO-inducing stimuli. Thus, silybin only blocked NO production induced by $IFN-{\gamma}$ but not LPS and the inhibition was increased when PMA was co-treated with $IFN-{\gamma}$. Unlike NO inhibition, however, this compound protected the cytotoxic damage of RAW264.7 cells induced by both LPS and $IFN-{\gamma}$. Therefore, our data suggest that silybin may participate in host immune responses mediated by T cells and macrophages via regulating mitogenic proliferation, and the production of $TNF-{\alpha}$ and NO, depending on cellular stimuli.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Silybin induces cell-cycle arrest and inhibits melanoma cell growth
한국실험동물학회 학술발표대회 논문집
2013 .08
-
Gram-Positive Bacteria Specific Properties of Silybin Derived from Silybum marianum
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2003 .01
-
간 보호제 및 담즙산류들이 마크로파지 세포주에서 TNF-${\alpha}$ 분비에 미치는 효과
약학회지
1998 .01
-
Microbial Metabolism Studies of Silybin, an Antihepatotoxic Flavonolignan
대한약학회 학술대회
2000 .01
-
인삼 사포닌류가 종양괴사인자의 생성 및 T 세포 증식에 미치는 효과
약학회지
1998 .01
-
Formulation and Biopharmaceutical Evaluation of Silymarin Using Self-MicroEmulsifying Drug Delivery Systems
대한약학회 학술대회
2003 .01
-
Formulation and Biopharmaceutical Evaluation of Self-Microemulsifying Drug Delivery Systems (SMEDDS) Containing Silymarin
대한약학회 학술대회
2003 .01
-
Eudesmin Inhibits Tumor Necrosis Factor-$\alpha$ Production and T cell Proliferation
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
1999 .01
-
Improved Dissolution Characteristics of Silymarin and Their Bioavailability in Human Volunteers
대한약학회 학술대회
2003 .01
-
설치류 대식세포에서 목향(木香) 추출물의 항염증 효과
동의생리병리학회지
2011 .01
-
대식세포에서 폐렴구균 협막 다당류에 의한 TNF-$\alpha$ 및 Nitric Oxide 생성
The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmacology
1998 .01
-
Differential Effects of TNF-α on the Survival and Apoptosis of Human Granulocytes and the Human Myeloid Leukemia Cell Line
대한의생명과학회지
2013 .06
-
Synthesis of novel compounds for the inhibition of TNF-$\alpha$ production
대한약학회 학술대회
2000 .01
-
엉겅퀴 추출물 실리마린의 피부 미백효과
대한화장품학회지
2009 .01
-
Retroviral Vector를 이용한 TNF-$\alpha$ 유전자의 이입이 암세포의 종양괴사인자(TNF) 감수성에 미치는 효과
Tuberculosis and Respiratory Diseases
1994 .01
-
The Production of IFN-${\gamma}$ by 3LL/TNF-$\alpha$-Activated Macrophages Requires p38. JAK-2 Signalling and is Enhanced by New Protein Synthesis.
대한약학회 학술대회
2002 .01
-
cAMP 증가 유도 약물의 대식세포- 및 T 세포-매개성 면역반응 조절작용
약학회지
2007 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0