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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 제30권 제7호
- 발행연도
- 2007.1
- 수록면
- 850 - 857 (8page)
이용수
초록· 키워드
오류제보하기
The aim is to investigate the effect of Magnolol preserved H460 cells from an oxidative agent tert-butylhydroperoxide (TBHP)-induced cell death. Magnolol augmented cell survival ratio after TBHP challenged. The protective action of this drug was more efficacious than that of N-acetylcysteine (NAC) which is a putative antioxidant. DNA damage, detected by the comet assay, was diminished after treatment of Magnolol. The cells viability decreased after treatment with 0.15 mM TBHP for 24 h, accompanied by inducing apoptotic death of the cells. Cytotoxicity and apoptosis induced by TBHP were significantly inhibited or attenuated after pretreatment with $20\;{\mu}M$ Magnolol. Magnolol contributes to the cells survival through downregulated the p53 phosphorylation and PTEN expression, and upregulated Akt phosphorylation. Taken together, Magnolol was effective against DNA single strand breaks (SSB) formation, cytotoxicity and lipid peroxidation induced by TBHP, and its effects on p53 phosphorlation, PTEN and Akt phosphorylation were due to its antioxidative function, and partially via a p53 dependent mechanism in this protective effects.
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Magnolol-Induced H460 Cells Death via Autophagy but Not Apoptosis
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
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Magnolol induces apoptosis via caspase-independent pathways in non-small cell lung cancer cells
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The protective role of magnolol on neuronal cell death induced by β-Amyloid Peptide
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Magnolol Inhibits iNOS, p38 Kinase, and NF-κB/Rel in Murine Macrophages
Toxicological Research
2006 .09
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Magnolol exerts anti-asthmatic effects by regulating Janus kinase-signal transduction and activation of transcription and Notch signaling pathways and modulating Th1/Th2/Th17 cytokines in ovalbumin-sensitized asthmatic mice
The Korean Journal of Physiology & Pharmacology
2019 .01
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Cytoprotective Effects of Docosyl Cafferate against tBHP-Induced Oxidative Stress in SH-SY5Y Human Neuroblastoma Cells
Biomolecules & Therapeutics(구 응용약물학회지)
2011 .01
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Effect of Baicalein on t-Butylhydroperoxide-Induced Cell Injury in Renal Tubular Epithelial Cells
대한의생명과학회지
2003 .12
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Anti-gastritic Effects of Magnolol and Honokiol from the Stem Bark of Magnolia obovata
Biomolecules & Therapeutics(구 응용약물학회지)
2008 .01
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Magnolol의 세라마이드에 의한 SK-N-SH 신경세포사멸에 대한 신경 보호효과에 대한 연구
해부·생물인류학
2020 .09
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Magnolol의 세라마이드에 의한 SK-N-SH 신경세포사멸에 대한 신경보호효과에 대한 연구
해부·생물인류학
2003 .06
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Antifungal Activity of Magnolol and Honokiol
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2000 .01
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The Effects of t-butylhydroperoxide (tBHP) and Juglandis Semen on Brain Na+-Pump Activity
Journal of Pharmacopuncture
1999 .01
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Renal epithelial cells에서 oxidant에 의한 apoptosis에 미치는 黃芩의 영향
대한한방내과학회지
2004 .01
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Protective Effects of Honokiol and Magnolol on t-Butyl Hydroperoxide or D-Galactosamine-Induced Toxicity in Rat Primary Hepatocytes
대한약학회 학술대회
2002 .01
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HepG2 세포에서 AMPK 활성화를 통한 호나복(胡蘿蔔) 에탄올 추출물의 간 세포 보호 효과
대한한의학방제학회지
2018 .01
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Antimicrobial Activities of Hydroxybiphenyl Derivatives (I)
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
1985 .01
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후박의 품질평가
약학회지
1997 .01
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Synergistic effect of lysozyme on bactericidal activity of magnolol and honokiol against a cariogenic bacterium, streptococcus mutans OMZ 176
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
1990 .01
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