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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 제30권 제6호
- 발행연도
- 2007.1
- 수록면
- 701 - 707 (7page)
이용수
초록· 키워드
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Senecio ambiguus subsp. ambiguus (Biv.) DC. extracts were able to inhibit the in vitro proliferation of renal cell adenocarcinoma ACHN and hormone dependent prostate carcinoma LNCaP. The potential cytotoxic property of the plant was revealed by the methanolic extractaction against LNCaP (IC$_{50}$ of 5.51 ${\mu}$g/mL) and ACHN (IC$_{50}$ of 38.95 ${\mu}$g/mL). The most Potent cytotoxic activity (IC$_{50}$ of 5.34 ${\mu}$g/mL against the prostate carcinoma cell line) was exerted by the dichloromethane extract. Through bioassay-guided fractionation of the dichlorormetnane extract jacaranone was isolated as the major active constituent. This quinoid showed a very strong activity against ACHN and LNcaP with IC$_{50}$ of 4.32 and 7.39 ${\mu}$g/mL, respectively. Its structure was established by GC/MS and NMR analysis. The n-hexane extract showed. an interesting inhibition on the proliferation of tumor cell lines an IC$_{50}$ value of 5.23 ${\mu}$g/mL against LNCaP. Three compounds identified in the n-hexane extract such as nerolidol, a-humulene and g-tocopherol were found to be active aginst LNCAP with IC$_{50}$ values ranged from 11.24 to 15.56 ${\mu}$g/mL.
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