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논문 기본 정보

자료유형
학술저널
저자정보
Kim, Dong-Woo (Department of Neurosurgery College of Medicine, Dong-A University) Sung, Soon-Ki (Department of Neurosurgery College of Medicine, Dong-A University) Song, Young-Jin (Department of Neurosurgery College of Medicine, Dong-A University) Choi, Soon-Seop (Department of Diagnostic Radiology College of Medicine, Dong-A University) Kim, Dae-Cheol (Department of Pathology College of Medicine, Dong-A University) Choi, Young-Min (Department of Radiation Oncology College of Medicine, Dong-A University) Huh, Won-Ju (Department of Radiation Oncology College of Medicine, Dong-A University) Kim, Ki-Uk (Department of Neurosurgery College of Medicine, Dong-A University)
저널정보
대한신경외과학회 대한신경외과학회지 대한신경외과학회지 제42권 제1호
발행연도
2007.1
수록면
27 - 34 (8page)

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Objective : On the magnetic resonance image (MRI) of the infiltrating brain tumor, enhancement is usually higher in malignant tumor than in benign tumor, and tumor cells can invade into the peritumoral area without definite enhancement. In various pathological conditions, the blood brain barrier (BBB) becomes changed to pathological condition, allowing various materials extravasating into the interstitial space, and degree of enhancement is depend on the pathology. Authors performed dynamic MRI on enhancing and surrounding edematous area in order to evaluate the degrees of opening of BBB, to differentiate tumor from non-tumorous condition, and to determine its relationship with the recurrence of the tumor. Methods : Dynamic MRI was performed in 25 patients. Dynamic scans were done every 15 seconds after administration of Gd-DTPA on the enhancing and surrounding area for maximum 300 seconds, and the patterns of enhancement were ana lysed. The enhancement curve with initial steep increase followed by slow decrease was defined as "N pattern", those with initial steep increase followed by additional slow increase as "T pattern", and those with initial steep increase followed by plateau as "E pattern". Histopathological findings were compared with the dynamic scan. Results : The graphs taken from enhancing area showed "T pattern" regardless of pathology. In the surrounding area, "T pattern" was noticed in the malignant tumors, but "E pattern" or "N pattern" was noted in low-grade or benign tumors and non-tumorous condition. "T pattern" in the surrounding area was related to the malignant with tumor cell infiltration and recurrence. Conclusion : The results suggest that the malignant tumor infiltration changes the condition of BBB enough to extravasate the Gd-DTPA. Enhancement pattern in the surrounding edematous area may be a useful information to differentiate the malignant glioma with the low-grade and benign tumors or other non-tumorous conditions.

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