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학제간연구 과학기술학 뇌인지과학 기술정책 기타 복합학

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논문 기본 정보

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학술저널
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Thu, Hlaing Myat (Department of Medical Research) Myat, Theingi Win (Department of Medical Research) Win, Mo Mo (Department of Medical Research) Thant, Kyaw Zin (Department of Medical Research) Rahman, Shofiqur (Immunology Research Institute in Gifu, EW Nutrition Japan) Umeda, Kouji (Immunology Research Institute in Gifu, EW Nutrition Japan) Nguyen, Sa Van (Immunology Research Institute in Gifu, EW Nutrition Japan) Icatlo, Faustino C. Jr. (Immunology Research Institute in Gifu, EW Nutrition Japan) Higo-Moriguchi, Kyoko (Department of Virology and Parasitology, Fujita Health University School of Medicin) Taniguchi, Koki (Department of Virology and Parasitology, Fujita Health University School of Medicin) Tsuji, Takao (Department of Microbiology, Fujita Health University School of Medicine) Oguma, Keiji (Department of Bacteriology, Okayama University Graduate School of Medicine) Kim, Sang Jong (Dairy Team, Lotte R&D Center) Bae, Hyun Suk (Dairy Team, Lotte R&D Center) Choi, Hyuk Joon (BK bio)
저널정보
한국축산식품학회 한국축산식품학회지 한국축산식품학회지 제37권 제1호
발행연도
2017.1
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1 - 9 (9page)

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The rotavirus-induced diarrhea of human and animal neonates is a major public health concern worldwide. Until recently, no effective therapy is available to specifically inactivate the rotavirion particles within the gut. Passive immunotherapy by oral administration of chicken egg yolk antibody (IgY) has emerged of late as a fresh alternative strategy to control infectious diseases of the alimentary tract and has been applied in the treatment of diarrhea due to rotavirus infection. The purpose of this concise review is to evaluate evidence on the properties and performance of anti-rotavirus immunoglobulin Y (IgY) for prevention and treatment of rotavirus diarrhea in human and animal neonates. A survey of relevant anti-rotavirus IgY basic studies and clinical trials among neonatal animals (since 1994-2015) and humans (since 1982-2015) have been reviewed and briefly summarized. Our analysis of a number of rotavirus investigations involving animal and human clinical trials revealed that anti-rotavirus IgY significantly reduced the severity of clinical manifestation of diarrhea among IgY-treated subjects relative to a corresponding control or placebo group. The accumulated information as a whole depicts oral IgY to be a safe and efficacious option for treatment of rotavirus diarrhea in neonates. There is however a clear need for more randomized, placebo controlled and double-blind trials with bigger sample size to further solidify and confirm claims of efficacy and safety in controlling diarrhea caused by rotavirus infection especially among human infants with health issues such as low birth weights or compromised immunity in whom it is most needed.
#Rotavirus #diarrhea disease #neonates #oral passive immunotherapy #IgY

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참고문헌 (38)

참고문헌 신청
Arimitsu, H. / 2014 / Evaluation of Shiga toxin 2e-specific chicken egg yolk immunoglobulin: Production and neutralization activity / Microbiol. Immunol 58:643~648 google schola Barnes, G. L. / 1982 / A randomised trial of oral gammaglobulin in low-birth-weight infants infected with rotavirus / The Lancet 319:1371~1373 google schola Bäumler, A. J. / 2016 / Interactions between the microbiota and pathogenic bacteria in the gut / Nature 535:85~93 google schola Bhavnani, D. / 2012 / Synergistic effects between rotavirus and coinfecting pathogens on diarrheal disease: Evidence from a community-based study in Northwestern Ecuador / Am. J. Epidemiol 176:387~395 google schola Dai, Y. C. / 2012 / Evaluation of anti-norovirus IgY from egg yolk of chickens immunized with norovirus P particles / J. Virol. Methods 186:126~131 google schola

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