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논문 기본 정보

자료유형
학술저널
저자정보
Kim, Byoung-Kook (Chong Kun Dang Bio Research Institute) Choi, In Suk (Chong Kun Dang Bio Research Institute) Kim, Jihee (Chong Kun Dang Bio Research Institute) Han, Sung Hee (BK21Plus, College of Health Science, Korea University) Suh, Hyung Joo (Department of Public Health Sciences, Graduate School, Korea University) Hwang, Jae-Kwan (Department of Biotechnology & Department of Biomaterials Science and Engineering, Yonsei University)
저널정보
한국축산식품학회 한국축산식품학회지 한국축산식품학회지 제37권 제6호
발행연도
2017.1
수록면
906 - 916 (11page)

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To investigate the effects of a single bacterium and a mixture of bacteria as probiotics in loperamide-treated animal models, loperamide (3 mg/kg) was administered to SD rats to induce constipation. The individual lactic acid bacterial doses, Enterococcus faecium (EF), Lactobacillus acidophilus (LA), Streptococcus thermophilus (ST), Bifidobacterium bifidum (BB), Bifidobacterium lactis (BL), Pediococcus pentosaceus (PP), and a mixture of the bacteria were orally administered to loperamide-induced constipated rats at a concentration of $10^8CFU/kg$ for 14 days. The weights and water contents of their stools were found to be significantly higher in PP, CKDB (mixture of 5 strains except PP), and CKDBP (CKDB+PP) groups than in the normal (constipation not induced) and the control (constipation-induced) groups (p<0.05). The intestinal transit ratio was significantly higher in all probiotic-treated groups than in the control group, and was the highest in the CKDBP group (p<0.05). The mucosal length and mucus secretion were significantly improved in all probiotic-treated-groups, as compared to that in the control group, and the CKDBP group was found to be the most effective according to immunohistochemistry (IHC) staining and total short chain fatty acid content analysis (p<0.05). Lastly, PP, CKDB, and CKDBP showed relatively higher Lactobacillus sp. ratios of 61.94%, 60.31% and 51.94%, respectively, compared to the other groups, based on metagenomic analysis.

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