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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.1
- 수록면
- 356 - 362 (7page)
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초록· 키워드
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We investigated the skin permeability and various biological activities of porcine homogenate of placenta (HP) with the highest protein contents (452.89 ${\mu}g/mg$). The content of protein in subcritical extract of HP (SPE) was decreased from the initial content of 452.9 ${\mu}g/mg$ to 262.7 ${\mu}g/mg$ at 3 h subcritical extract. The contents of amino type nitrogen (A-N) were sharply increased from 35.1 ${\mu}g/mg$ of initial content to 305.9 ${\mu}g/mg$ at 3 h subcritical extract. The HP showed a noticeable activity in terms of antioxidant capacity for ferric reducing antioxidant power (FRAP) assay and especially for 2,2'-Azinobis- (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) method. HP, SPE-0.5, SPE-2 and SPE-3 showed inhibitory effect on elastase activities with an $IC_{50}$ of 46.1, 42.9, 31.6 and 34.7 ${\mu}g/mL$, respectively. SPEs showed more significantly inhibitory effect than HP (p<0.05). The skin permeability of the SPEs was higher than that of the HP. SPE-3 showed highest skin permeation and the permeability was significantly higher than that of HP. SPE-2 also showed significantly higher permeation than HP after 4 h. As expected, increase of extraction time significantly increased skin permeability in the subcritical extract of HP (SPE). From these results, in terms of cost and source availability, porcine placenta extracted with subcritical extraction has advantages over untreated PE and have potential as a cosmetic ingredient.
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참고문헌 (32)
참고문헌 신청
Adler-Nissen, J. / 1979 / Determination of the degree of hydrolysis of food protein hydrolysates by trinitrobenzenesulfonic acid / J. Agric. Food Chem 27:1256~1262
An, B. J. / 2005 / Inhibition of enzyme activities and the antiwrinkle effect of polyphenol isolated from the persimmon leaf (Diospyros kaki folium) on human skin / Dermatol. Surg 31:848~854
Benzie, I. F. F / 1996 / The ferric reducing ability of plasma (FRAP) as a measure of “ntioxidant power” the FRAP assay / Anal. Biochem 239:70~76
Bos, J. D. / 2000 / The 500 Dalton rule for the skin penetration of chemical compounds and drugs / Exp. Dermatol 9:165~169
Briganti, S / 2003 / Chemical and instrumental approaches to treat hyperpigmentation / Pigment Cell Res 16:101~110
An, B. J. / 2005 / Inhibition of enzyme activities and the antiwrinkle effect of polyphenol isolated from the persimmon leaf (Diospyros kaki folium) on human skin / Dermatol. Surg 31:848~854
Benzie, I. F. F / 1996 / The ferric reducing ability of plasma (FRAP) as a measure of “ntioxidant power” the FRAP assay / Anal. Biochem 239:70~76
Bos, J. D. / 2000 / The 500 Dalton rule for the skin penetration of chemical compounds and drugs / Exp. Dermatol 9:165~169
Briganti, S / 2003 / Chemical and instrumental approaches to treat hyperpigmentation / Pigment Cell Res 16:101~110
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