지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 229 - 236 (8page)
이용수
초록· 키워드
오류제보하기
The glycoprotein hormone family represents a class of heterodimers, that includes the placental hormone equine chorionic gonadotropin (eCG) and the anterior pituitary hormones- follitropin (FSH), lutropin (LH), and thyrotropin (TSH). The 4 hormones are heterodimers, with a common $\alpha$-subunit and unique $\beta$-subunits. eCG is the most heavily glycosylated of the known pituitary and placental glycoprotein hormones. Recent observations using single chain glycoprotein hormone analogs in which, the $\beta$-and $\alpha$-subunits are linked, implied that heterodimeric-like quaternary configuration is not a prerequisite for receptor/signal transduction. To study the function and signal transduction of tethered rec-eCG, a single chain eCG molecule was constructed and rec-eCG protein was produced. Molecular mass of the single chain is about 45 kDa. All mice were ovulated by tethered rec-eCG treatment. The dual activity of tethered rec-eCG was determined in receptor cell lines of nonequid species; in fact, this dual activity was proven in species other than horse. Tethered rec-eCG in equids does not bind to FSH receptors, suggesting that eCG is primarily an LH-like hormone in the horse. Taken together, these data suggest that tethered rec-eCG has dual activity in nonequid species in vitro. However, it has only LH-like activity in equid species in vitro.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
$\beta$-Subunit 94~96 Residues of Tethered Recombinant Equine Chorionic Gonadotropin are Important Sites for Luteinizing Hormone and Follicle Stimulating Hormone like Activities
한국동물번식학회지
2010 .01
-
Biological Functions of N- and O-linked Oligosaccharides of Equine Chorionic Gonadotropin and Lutropin/Chorionicgonadotropin Receptor
한국동물번식학회 심포지움
2000 .01
-
Biological Functions of N- and O-linked Oligosaccharides of Equine Chorionic Gonadotropin and Lutropin/Chorionic Gonadotropin Receptor
한국동물번식학회지
2000 .01
-
Biological activities of tethered-eCG ${\alpha}$-subunit COOH-terminal region
한국수정란이식학회 심포지움
2005 .01
-
Biological Functions of the COOH-Terminal Amino Acids of the $\alpha$-Subunit of Tethered Equine Chorionic Gonadotropin
한국동물번식학회지
2010 .01
-
On the Secretion and Functions of Equine Chorionic Gonadotropin
한국동물번식학회지
2000 .01
-
COOH-Terminal Animo Acids of Tethered-Buman Glycoprotein Bormone $\alpha$-Subunit Play an Important Role for Secretion
한국가축번식학회지
2002 .01
-
Biological Function of Single Chain Glycoprotein Hormone Mutants
한국동물번식학회 학술대회
2001 .01
-
Identification and Characterization for Agonist-induced Internalization of LH/CG and FSH Receptors by Recombinant eCG Mutants
한국수정란이식학회 심포지움
2006 .01
-
Signal Transduction of Equine Follicle-Stimulating Hormone Receptor (eFSHR) by rec-eelFSHβ/α, Natural Porcine FSH, and Natural Human FSH
한국동물번식학회지
2018 .01
-
Functional Expression of Lutropin/Choriogonadotropin and Follitropin Receptor cDNAs in 293 Cells
한국동물번식학회지
1999 .01
-
FSH 활성 특정부위 분석을 위한 eCG 돌연변이체의 기능 분석
한국동물번식학회 학술대회
2004 .01
-
녹차, 오룡차 및 홍차 추출물의 Xanthine Oxidase 억제작용
한국식품영양과학회지
1995 .01
-
Effects of MMP-2 activation and FSH or LH Hormone Supplementation on Embryo Development in In Vitro Fertilization of Porcine
한국수정란이식학회지
2018 .01
-
Ectopic Expression of Tethered Human Follicle-Stimulating Hormone (hFSH) Gene in Transgenic Mice
한국수정란이식학회 심포지움
2006 .01
-
Birth of a Siberian Tiger Cub from an Albino Mother Tiger with Help of eCG and hCG
한국수정란이식학회지
2011 .01
-
Biological Activity of Recombinant Human Erythropoietin (EPO) In Vivo and In Vitro
한국동물번식학회지
2005 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0