지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Objectives : Obsessive-compulsive(OC) symptoms have yet to be directly studied in neurodegenerative conditions involving behavioral changes. To examine regional abnormalities in the brains of dementia patients with OC symptoms, we assessed the gray matter density using voxel-based morphometry(VBM). Methods : We performed brain magnetic resonance imaging(MRI) with VBM analysis in 106 dementia patients with OC behaviors. In this study, OC behaviors were investigated in patients with neurodegenerative disease using the modified Manchester Behavior Questionnaire. Results : The OC behavior scores were correlated with structural brain volume using VBM. The total OC symptom score correlated negatively with the volume of both putamens, the right middle orbitofrontal gyrus, both anterior cingulate cortices, and the left insula(p<0.001, uncorrected). No gray matter reductions were associated specifically with the OC symptom sub-categories. Conclusions : Our results suggest that abnormalities in these brain regions may play an important role in the pathophysiology of OCD in neurodegenerative disease. This is the first lesion study to investigate the neural basis of OCD behaviors in neurodegenerative disease.
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참고문헌 (46)
참고문헌 신청
Kang DH / 2004 / Volumetric investigation of the frontal-subcortical circuitry in patients with obsessive-compulsive disorder / J Neuropsychiatry Clin Neurosci 16:342~349
Baxter LR / 1992 / Caudate glucose metabolic rate changes with both drug and behavior therapy for obsessive-compulsive disorder / Arch Gen Psychiatry 49:681~689
Baxter LR / 1994 / Positron emission tomography studies of cerebral glucose metabolism in obsessive compulsive disorder / J Clin Psychiatry 55(suppl):54~59
Zald DH / 1996 / Anatomy and function of the orbital frontal cortex, I: anatomy, neurocircuitry, and obsessive-compulsive disorder / J Neuropsychiatry Clin Neurosci 8:125~138
Zald DH / 1996 / Anatomy and function of the orbital frontal cortex, II: function and relevance to obsessive-compulsive disorder / J Neuropsychiatry Clin Neurosci 8:249~261
Baxter LR / 1992 / Caudate glucose metabolic rate changes with both drug and behavior therapy for obsessive-compulsive disorder / Arch Gen Psychiatry 49:681~689
Baxter LR / 1994 / Positron emission tomography studies of cerebral glucose metabolism in obsessive compulsive disorder / J Clin Psychiatry 55(suppl):54~59
Zald DH / 1996 / Anatomy and function of the orbital frontal cortex, I: anatomy, neurocircuitry, and obsessive-compulsive disorder / J Neuropsychiatry Clin Neurosci 8:125~138
Zald DH / 1996 / Anatomy and function of the orbital frontal cortex, II: function and relevance to obsessive-compulsive disorder / J Neuropsychiatry Clin Neurosci 8:249~261
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