지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 248 - 252 (5page)
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Background Patients with diabetes mellitus often have a difficult life, suffering from foot ulceration or amputation. Diabetes is characterized by chronic inflammation, and one of the features of inflammation is hypoxia. Recently, it has been reported that KAI1 is a hypoxia target gene. There is no published research on hypoxia-related KAI1 protein levels in human diabetic skin. Therefore, we have investigated the expression of KAI1 protein in diabetic skin tissue in vivo. Methods The expression of KAI1 protein was evaluated by western blotting in 6 diabetic skin tissue samples and 6 normal skin samples. Immunohistochemical staining was carried out to identify KAI1 expression. Results The western blotting revealed significantly increased expression of the KAI1 protein in diabetic skin tissues as compared to normal skin tissues. Immunohistochemical examination demonstrated that KAI1 was expressed in all diabetic skin tissues with moderate-to-strong positivity and weakly expressed in normal skin tissues. Conclusions Our data suggest that a high expression of the KAI1 protein can be observed in diabetic skin tissue. To the best of our knowledge, this is the first report suggesting that KAI1 protein expression in diabetic skin tissues may be associated with chronic inflammatory states and hypoxia.
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참고문헌 (20)
참고문헌 신청
Cheng K / 2010 / Hypoxia-inducible factor-1alpha regulates beta cell function in mouse and human islets / J Clin Invest 120:2171~2183
Carroll VA / 2006 / Ashcroft M. Role of hypoxia-inducible factor (HIF)-1alpha versus HIF-2alpha in the regulation of HIF target genes in response to hypoxia, insulin-like growth factor-I, or loss of von Hippel-Lindau function: implications for targeting the HIF pathway / Cancer Res 66:6264~6270
Ahmad FK / 2005 / Molecular targets of diabetic cardiovascular complications / Curr Drug Targets 6:487~494
Fraisl P / 2009 / Inhibition of oxygen sen-sors as a therapeutic strategy for ischaemic and inflamma-tory disease / Nat Rev Drug Discov 8:139~152
Karhausen J / 2005 / Inflammatory hypoxia:role of hypoxia-inducible factor / Cell Cycle 4:256~258
Carroll VA / 2006 / Ashcroft M. Role of hypoxia-inducible factor (HIF)-1alpha versus HIF-2alpha in the regulation of HIF target genes in response to hypoxia, insulin-like growth factor-I, or loss of von Hippel-Lindau function: implications for targeting the HIF pathway / Cancer Res 66:6264~6270
Ahmad FK / 2005 / Molecular targets of diabetic cardiovascular complications / Curr Drug Targets 6:487~494
Fraisl P / 2009 / Inhibition of oxygen sen-sors as a therapeutic strategy for ischaemic and inflamma-tory disease / Nat Rev Drug Discov 8:139~152
Karhausen J / 2005 / Inflammatory hypoxia:role of hypoxia-inducible factor / Cell Cycle 4:256~258
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