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논문 기본 정보

자료유형
학술저널
저자정보
Halim, Ahmad Sukari (Reconstructive Sciences Unit, School of Medical Sciences, Universiti Sains Malaysia) Wan Ahmad Kamal, Wan Syazli Rodzaian (Reconstructive Sciences Unit, School of Medical Sciences, Universiti Sains Malaysia) Noor, Norizal Mohd (Faculty of Medicine, MARA Institute of Technology University [UiTM]) Abdullah, Shafie (Reconstructive Sciences Unit, School of Medical Sciences, Universiti Sains Malaysia)
저널정보
대한성형외과학회 Archives of plastic surgery : APS Archives of plastic surgery : APS 제40권 제6호
발행연도
2013.1
수록면
687 - 696 (10page)

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Background Ischemic preconditioning has been shown to improve the outcomes of hypoxic tolerance of the heart, brain, lung, liver, jejunum, skin, and muscle tissues. However, to date, no report of ischemic preconditioning on vascularized bone grafts has been published. Methods Sixteen rabbits were divided into four groups with ischemic times of 2, 6, 14, and 18 hours. Half of the rabbits in each group underwent ischemic preconditioning. The osteomyocutaneous flaps consisted of the tibia bone, from which the overlying muscle and skin were raised. The technique of ischemic preconditioning involved applying a vascular clamp to the pedicle for 3 cycles of 10 minutes each. The rabbits then underwent serial plain radiography and computed tomography imaging on the first, second, fourth, and sixth postoperative weeks. Following this, all of the rabbits were sacrificed and histological examinations were performed. Results The results showed that for clinical analysis of the skin flaps and bone grafts, the preconditioned groups showed better survivability. In the plain radiographs, except for two non-preconditioned rabbits with intraoperative ischemic times of 6 hours, all began to show early callus formation at the fourth week. The computed tomography findings showed more callus formation in the preconditioned groups for all of the ischemic times except for the 18- hour group. The histological findings correlated with the radiological findings. There was no statistical significance in the difference between the two groups. Conclusions In conclusion, ischemic preconditioning improved the survivability of skin flaps and increased callus formation during the healing process of vascularized bone grafts.

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