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논문 기본 정보

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학술저널
저자정보
Chung, Kun Il (Department of Plastic and Reconstructive Surgery, Chung-Ang University Hospital, Chung-Ang University College of Medicine) Kim, Han Koo (Department of Plastic and Reconstructive Surgery, Chung-Ang University Hospital, Chung-Ang University College of Medicine) Kim, Woo Seob (Department of Plastic and Reconstructive Surgery, Chung-Ang University Hospital, Chung-Ang University College of Medicine) Bae, Tae Hui (Department of Plastic and Reconstructive Surgery, Chung-Ang University Hospital, Chung-Ang University College of Medicine)
저널정보
대한성형외과학회 Archives of plastic surgery : APS Archives of plastic surgery : APS 제40권 제3호
발행연도
2013.1
수록면
181 - 186 (6page)

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Background Partial or complete necrosis of a skin flap is a common problem. Polydeoxyribonucleotide (PDRN) can be extracted from trout sperm and used as a tissue repair agent. The aim of this study was to investigate whether PDRN could improve the survival of random pattern skin flaps in rats. Methods Twenty-two male Sprague-Dawley rats were randomly divided into two groups: the PDRN treatment group (n=11) and the control group (n=11). Caudally pedicled random pattern skin flaps were elevated on their dorsal skin and resutured. The treatment group received daily intraperitoneal administration of PDRN (8 mg/kg/day), and the control group received fluid vehicle (NaCl 0.9%, 8 mg/kg/day) from day 0 to day 6. On day 7, the flap survival was evaluated and the harvested tissue surrounding the demarcation line of the necrotic area was stained with H&E, anti-rat vascular endothelial cell growth factor (VEGF) antibody, and PECAM-1/CD31 antibody. Results The average necrotic area of the flap in the PDRN group was significantly smaller when compared with that of the control group. Histologic and immunohistochemical evaluation showed that granulation thickness score and VEGF-positive staining cells were marked higher in the PDRN group than in the control group. PECAM-1/CD31-positive microvascular densities were significantly higher in the PDRN group when compared with the control group. Conclusions This study confirms that PDRN improves the survival of random pattern skin flaps in rats. These results may represent a new therapeutic approach to enhancing flap viability and achieving faster wound repair.
#Polydeoxyribonucleotides #Surgical flaps #Angiogenesis modulating agents #Vascular endothelial growth factors #Antigens, CD31

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참고문헌 (24)

참고문헌 신청
Folkman J / 1992 / Angiogenesis / J Biol Chem 267:10931~10934 google schola Akhavani MA / 2008 / Angiogenesis and plastic surgery / J Plast Reconstr Aesthet Surg 61:1425~1437 google schola Padubidri A / 1996 / Effect of vascular endothelial growth factor (VEGF) on survival of random extension of axial pattern skin flaps in the rat / Ann Plast Surg 37:604~611 google schola Kryger Z / 2000 / The effects of VEGF on survival of a random flap in the rat: examination of various routes of administration / Br J Plast Surg 53:234~239 google schola Pierce GF / 1992 / Platelet-derived growth factor (BB homodimer), transforming growth factor-beta 1, and basic fibroblast growth factor in dermal wound healing. Neovessel and matrix formation and cessation of repair / Am J Pathol 140:1375~1388 google schola

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