지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.1
- 수록면
- 530 - 535 (6page)
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초록· 키워드
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Background Platelet-rich plasma (PRP) has more concentrated platelets than normal plasma (approximately 150-400${\times}10^3$ cell/dL). Platelets excrete several growth factors and cytokines that are associated with the healing and regeneration process. However, even though PRP is widely used, the mechanism or actual effect is presently unclear. Therefore, this study was performed to investigate the levels of growth factors and platelet concentration rate. Methods Autologous blood for preparing PRP was obtained from healthy subjects aged 25 to 35 years. The samples were divided into 4 experimental groups (inactivated whole blood, inactivated PRP, activated whole blood with thrombin and calcium chloride, and activated PRP). The platelet counts in the blood were analyzed and the growth factors were quantitatively measured. A statistical analysis was performed by using Dunn's multiple comparison test. Results In the blood cell analysis, the platelet count of the PRP group was approximately 4.25 times higher than that of the whole blood group. In the quantitative analysis of growth factors, the platelet-derived growth factor (PDGF)-AB, PDGF-BB, and transforming growth factor-${\beta}$ of the inactivated and activated PRP groups were higher than those of the inactivated and activated whole blood groups (P<0.05). Conclusions In this study, the platelet count and the levels of PDGF-AB and PDGF-BB in the PRP were determined. Further, more research is required on the bioactivity level of the growth factors secreted during the process of PRP preparation and the potency of growth factors that can be exerted physiologically in vivo.
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참고문헌 (17)
참고문헌 신청
Whitman DH / 1997 / Platelet gel: an autologous alternative to fibrin glue with applications in oral and maxillofacial surgery / J Oral Maxillofac Surg 55:1294~1299
Bhanot S / 2002 / Current applications of platelet gels in facial plastic surgery / Facial Plast Surg 18:27~33
Margolis DJ / 2001 / Effectiveness of platelet releasate for the treatment of diabetic neuropathic foot ulcers / Diabetes Care 24:483~488
Marx RE / 1998 / Platelet-rich plasma: Growth factor enhancement for bone grafts / Oral Surg Oral Med Oral Pathol Oral Radiol Endod 85:638~646
Kevy SV / 2004 / Comparison of methods for point of care preparation of autologous platelet gel / J Extra Corpor Technol 36:28~35
Bhanot S / 2002 / Current applications of platelet gels in facial plastic surgery / Facial Plast Surg 18:27~33
Margolis DJ / 2001 / Effectiveness of platelet releasate for the treatment of diabetic neuropathic foot ulcers / Diabetes Care 24:483~488
Marx RE / 1998 / Platelet-rich plasma: Growth factor enhancement for bone grafts / Oral Surg Oral Med Oral Pathol Oral Radiol Endod 85:638~646
Kevy SV / 2004 / Comparison of methods for point of care preparation of autologous platelet gel / J Extra Corpor Technol 36:28~35
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