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논문 기본 정보

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학술저널
저자정보
Yang, Jung Dug (Department of Plastic and Reconstructive Surgery, Kyungpook National University School of Medicine) Choi, Dong Sik (Department of Plastic and Reconstructive Surgery, Kyungpook National University School of Medicine) Cho, Young Kyoo (Department of Plastic and Reconstructive Surgery, Kyungpook National University School of Medicine) Kim, Taek Kyun (Department of Plastic and Reconstructive Surgery, Kyungpook National University School of Medicine) Lee, Jeong Woo (Department of Plastic and Reconstructive Surgery, Kyungpook National University School of Medicine) Choi, Kang Young (Department of Plastic and Reconstructive Surgery, Kyungpook National University School of Medicine) Chung, Ho Yun (Department of Plastic and Reconstructive Surgery, Kyungpook National University School of Medicine) Cho, Byung Chae (Department of Plastic and Reconstructive Surgery, Kyungpook National University School of Medicine) Byun, Jin Suk (BS Aesthetic Clinic)
저널정보
대한성형외과학회 Archives of plastic surgery : APS Archives of plastic surgery : APS 제40권 제5호
발행연도
2013.1
수록면
496 - 504 (9page)

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Background Amniotic-fluid-derived stem cells and amniocytes have recently been determined to have wound healing effects, but their mechanism is not yet clearly understood. In this study, the effects of amniotic fluid stem cells and amniocytes on wound healing were investigated through animal experiments. Methods On the back of Sprague-Dawley rats, four circular full-thickness skin wounds 2 cm in diameter were created. The wounds were classified into the following four types: a control group using Tegaderm disc wound dressings and experimental groups using collagen discs, amniotic fluid stem cell discs, and amniocyte discs. The wounds were assessed through macroscopic histological examination and immunohistochemistry over a period of time. Results The amniotic fluid stem cell and amniocyte groups showed higher wound healing rates compared with the control group; histologically, the inflammatory cell invasion disappeared more quickly in these groups, and there was more significant angiogenesis. In particular, these groups had significant promotion of epithelial cell reproduction, collagen fiber formation, and angiogenesis during the initial 10 days of the wound healing process. The potency of transforming growth factor-${\beta}$ and fibronectin in the experimental group was much greater than that in the control group in the early stage of the wound healing process. In later stages, however, no significant difference was observed. Conclusions The amniotic fluid stem cells and amniocytes were confirmed to have accelerated the inflammatory stage to contribute to an enhanced cure rate and shortened wound healing period. Therefore, they hold promise as wound treatment agents.
#Amniotic fluid #Stem cells #Wound healing

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참고문헌 (13)

참고문헌 신청
Dev K / 2012 / Derivation, characterization and differentiation of buffalo (Bubalus bubalis) amniotic fluid derived stem cells / Reprod Domest Anim 47:704~711 google schola Jaramillo-Ferrada PA / 2012 / Differential mesengenic potential and expression of stem cellfate modulators in mesenchymal stromal cells from humanterm placenta and bone marrow / J Cell Physiol 227:3234~3242 google schola Tauzin H / 2011 / Human amniotic membrane in the management of chronic venous leg ulcers / Ann Dermatol Venereol 138:572~579 google schola Uberti MG / 2011 / Amnion-derived cellular cytokine solution promotes macrophage activity / Ann Plast Surg 66:575~580 google schola Gosden CM / 1983 / Amniotic fluid cell types and culture / Br Med Bull 39:348~354 google schola

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