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논문 기본 정보

자료유형
학술저널
저자정보
Cai, Elijah Zhengyang (Department of Surgery, National University Health System) Teo, Erin Yiling (Department of Reproductive Medicine, KK Women's and Children Hospital) Jing, Lim (Division of Bioengineering, School of Chemical and Biomedical Engineering, Nanyang Technological University) Koh, Yun Pei (Department of Surgery, National University Health System) Qian, Tan Si (Centre for Biomedical Materials Applications and Technology [BIOMAT], Department of Mechanical Engineering, Faculty of Engineering, National University of Singapore) Wen, Feng (Division of Bioengineering, School of Chemical and Biomedical Engineering, Nanyang Technological University) Lee, James Wai Kit (Department of Surgery, National University Health System) Hing, Eileen Chor Hoong (Department of Surgery, National University of Singapore) Yap, Yan Lin (Division of Plastic, Reconstructive and Aesthetic Surgery, Department of Surgery, National University Health System) Lee, Hanjing (Division of Plastic, Reconstructive and Aesthetic Surgery, Department of Surgery, National University Health System) Lee, Chuen Neng (Department of Surgery, National University of Singapore) Teoh, Swee-Hin (Division of) Lim, Jane Lim, Thiam Chye
저널정보
대한성형외과학회 Archives of plastic surgery : APS Archives of plastic surgery : APS 제41권 제6호
발행연도
2014.1
수록면
638 - 646 (9page)

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Background The combination of polycaprolactone and hyaluronic acid creates an ideal environment for wound healing. Hyaluronic acid maintains a moist wound environment and accelerates the in-growth of granulation tissue. Polycaprolactone has excellent mechanical strength, limits inflammation and is biocompatible. This study evaluates the safety and efficacy of bio-conjugated polycaprolactone membranes (BPM) as a wound dressing. Methods 16 New Zealand white rabbits were sedated and local anaesthesia was administered. Two $3.0{\times}3.0cm$ full-thickness wounds were created on the dorsum of each rabbit, between the lowest rib and the pelvic bone. The wounds were dressed with either BPM (n=12) or Mepitel (n=12) (control), a polyamide-silicon wound dressing. These were evaluated macroscopically on the 7th, 14th, 21st, and 28th postoperative days for granulation, re-epithelialization, infection, and wound size, and histologically for epidermal and dermal regeneration. Results Both groups showed a comparable extent of granulation and re-epithelialization. No signs of infection were observed. There was no significant difference (P>0.05) in wound size between the two groups. BPM (n=6): $8.33cm^2$, $4.90cm^2$, $3.12cm^2$, $1.84cm^2$; Mepitel (n=6): $10.29cm^2$, $5.53cm^2$, $3.63cm^2$, $2.02cm^2$; at the 7th, 14th, 21st, and 28th postoperative days. The extents of epidermal and dermal regeneration were comparable between the two groups. Conclusions BPM is comparable to Mepitel as a safe and efficacious wound dressing.
#Skin #Wounds #Hyaluronic acid #Polycaprolactone #Rabbit

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참고문헌 (25)

참고문헌 신청
Pontieri-Lewis V / 1999 / Principles for selecting the right wound dressing / Medsurg Nurs 8:267~270 google schola Teo EY / 2011 / Polycaprolactone-based fused deposition modeled mesh for delivery of antibacterial agents to infected wounds / Biomaterials 32:279~287 google schola Hutmacher DW / 2000 / Scaffolds in tissue engineering bone and cartilage / Biomaterials 21:2529~2543 google schola Chen WY / 1999 / Functions of hyaluronan in wound repair / Wound Repair Regen 7:79~89 google schola Tiaw KS / 2007 / Processing methods of ultrathin poly(epsilon-caprolactone) films for tissue engineering applications / Biomacromolecules 8:807~816 google schola

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