Mesothelioma in Sweden: Dose-Response Analysis for Exposure to 29 Potential Occupational Carcinogenic Agents

Plato, Nils; Martinsen, Jan I.; Kjaerheim, Kristina; Kyyronen, Pentti; Sparen, Par; Weiderpass, Elisabete

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자료유형: 학술저널

저자정보: Plato, Nils (Institute of Environmental Medicine, Karolinska Institutet) Martinsen, Jan I. (Department of Research, Cancer Registry of Norway, Institute of Population-Based Cancer Research) Kjaerheim, Kristina (Department of Research, Cancer Registry of Norway, Institute of Population-Based Cancer Research) Kyyronen, Pentti (Finnish Cancer Registry) Sparen, Par (Department of Medical Epidemiology and Biostatistics, Karolinska Institutet) Weiderpass, Elisabete (Department of Research, Cancer Registry of Norway, Institute of Population-Based Cancer Research)

저널정보: 산업안전보건연구원 Safety and health at work : SH@W Safety and health at work : SH@W 제9권 제3호

발행연도: 2018.1

수록면: 290 - 295 (6page)

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Background: There is little information on the dose-response relationship between exposure to occupational carcinogenic agents and mesothelioma. This study aimed to investigate this association as well as the existence of agents other than asbestos that might cause mesothelioma. Methods: The Swedish component of the Nordic Occupational Cancer (NOCCA) study consists of 6.78 million individuals with detailed information on occupation. Mesothelioma diagnoses recorded in 1961-2009 were identified through linkage to the Swedish Cancer Registry. We determined cumulative exposure, time of first exposure, and maximum exposure intensity by linking data on occupation to the Swedish NOCCA job-exposure matrix, which includes 29 carcinogenic agents and corresponding exposure for 283 occupations. To assess the risk of mesothelioma, we used conditional logistic regression models to estimate hazard ratios and 95% confidence intervals. Results: 2,757 mesothelioma cases were identified in males, including 1,416 who were exposed to asbestos. Univariate analyses showed not only a significant excess risk for maximum exposure intensity, with a hazard ratio of 4.81 at exposure levels 1.25-2.0 fb/ml but also a clear dose-response effect for cumulative exposure with a 30-, 40-, and 50-year latency time. No convincing excess risk was revealed for any of the other carcinogenic agents included in the Swedish NOCCA job-exposure matrix. Conclusion: When considering asbestos exposure, past exposure, even for short periods, might be enough to cause mesothelioma of the pleura later in life.

#Asbestos #Dose-response #Mesothelioma #Pleura

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