지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 149 - 158 (10page)
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초록· 키워드
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Photo-protective properties of Polysiphonia morrowii ethanol extract (PME) against ultraviolet B (UVB) radiation-induced cellular damage were investigated in human HaCaT keratinocytes. PME exhibited scavenging activity against 1,1-diphenyl-2-picrylhydrazyl radical and intracellular reactive oxygen species induced by either hydrogen peroxide ($H_2O_2$) or UVB radiation. In addition, PME scavenged superoxide anion generated by xanthine/xanthine oxidase system and hydroxyl radical generated by the Fenton reaction ($FeSO_4+H_2O_2$), both of which were detected using electron spin resonance spectrometry. Moreover, PME, which scavenges $H_2O_2$, was shown to contain the antioxidant compound 3-bromo-4,5-dihydroxylbenzaldehyde, possibly accounting for scavenging actions. PME also restored the levels of catalase and superoxide dismutase protein expression and activity that were decreased by UVB radiation. PME reduced UVB-induced apoptosis, as shown by decreased apoptotic bodies and DNA fragmentation. These results indicate that PME protects human keratinocytes against oxidative stress induced by UVB radiation through the enhancement of antioxidant systems.
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